{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as important regulators in both developmental and oncogenic processes, with recent studies highlighting their potential as biomarkers. While analysis of the lncRNA transcriptome in congenital heart disease, such as ventricular septal defects, and head and neck squamous cell carcinoma (HNSCC) has expanded our understanding of lncRNA involvement in diverse pathologies"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", a specific lncRNA—FGF10‐AS1—has been identified in triple‐negative breast cancer (TNBC) as having significant prognostic implications. In a comprehensive study analyzing RNA-sequencing data, FGF10-AS1 was one of the lncRNAs whose expression levels were significantly associated with overall survival in TNBC patients, and its inclusion in a three-lncRNA prognostic signature provided an independent predictor of patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " This finding suggests that FGF10-AS1, beyond being a mere marker of disease status, may play a role in the complex molecular networks underlying TNBC progression, reinforcing the emerging concept that lncRNAs serve as critical components in disease mechanisms and potential targets for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guixian Song, Yahui Shen, Jingai Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of dysregulated lncRNA expression in fetal cardiac tissues with ventricular septal defect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0077492"}], "href": "https://doi.org/10.1371/journal.pone.0077492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24147006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24147006"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nijiro Nohata, Martin C Abba, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oraloncology.2016.05.014"}], "href": "https://doi.org/10.1016/j.oraloncology.2016.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27424183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27424183"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chun-Ni Fan, Lei Ma, Ning Liu "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of novel three-long noncoding RNA signatures as a diagnostic and prognostic biomarkers of human triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27584"}], "href": "https://doi.org/10.1002/jcb.27584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30203490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30203490"}]}]}]}