{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have underscored the importance of long non‐coding RNAs (lncRNAs) in breast cancer, with lncRNA FGF13‑AS1 emerging as a key tumor suppressor. In breast cancer tissues, FGF13‑AS1 is downregulated compared with normal tissue, and its reduced expression correlates with poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional investigations have demonstrated that FGF13‑AS1 inhibits cancer cell proliferation, migration, and invasion by impairing glycolysis and the stemness properties of breast cancer cells. Mechanistically, FGF13‑AS1 exerts its suppressive effect by binding to insulin‐like growth factor 2 mRNA binding proteins (IGF2BPs), thereby disrupting their interaction with c‑Myc mRNA and reducing its half‑life. This regulation forms the basis of a negative feedback loop, since c‑Myc in turn transcriptionally represses FGF13‑AS1 expression.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n These findings are set against a broader backdrop in which various lncRNAs have been implicated in the regulation of tumorigenesis, cancer cell metabolism, and stemness. For instance, while other lncRNAs such as CERS6‑AS1 and ARAP1‑AS1 have been shown to promote breast and cervical cancer progression through modulation of mRNA stability via interactions with RNA‑binding proteins like IGF2BP3 and PSF, respectively"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", comprehensive reviews have also highlighted the dual oncogenic and tumor‑suppressive roles of non‑coding RNAs in breast cancer and cancer stem cell regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, investigations into genomic rearrangements, such as the insertion events at Xq27.1, further expand our understanding of how non‑coding genomic elements may contribute to disease phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, FGF13‑AS1 functions as a tumor suppressor in breast cancer by perturbing IGF2BP‑mediated stabilization of c‑Myc mRNA, thereby inhibiting metabolic reprogramming and stemness traits that are essential for tumor progression. These insights illuminate potential therapeutic avenues targeting the FGF13‑AS1/IGF2BPs/c‑Myc regulatory loop in breast cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Ma, Xu Liu, Shibo Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.02.008"}], "href": "https://doi.org/10.1016/j.canlet.2019.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30771425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30771425"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang Bao, Jianjun Huang, Wei Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2675"}], "href": "https://doi.org/10.1002/cam4.2675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31701672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31701672"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yao Zhang, Dan Wu, Dian Wang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ARAP1-AS1 promotes tumorigenesis and metastasis through facilitating proto-oncogene c-Myc translation via dissociating PSF/PTB dimer in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2860"}], "href": "https://doi.org/10.1002/cam4.2860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31953923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31953923"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kirti S Prabhu, Afsheen Raza, Thasni Karedath, et al. 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