{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FGF14‐AS2 is a long non‐coding RNA (lncRNA) that appears to play context‐dependent roles in cancer. In breast cancer, colorectal cancer, and prostate carcinoma, FGF14‐AS2 is frequently downregulated and functions as a tumor suppressor. In these cancers, its overexpression or restoration suppresses cell proliferation, migration, and invasion while promoting apoptosis. Mechanistically, FGF14‐AS2 acts as a competing endogenous RNA (ceRNA): in breast cancer it binds to miR‑205‑5p to counteract its oncogenic effects and, in another study, sponges miR‑370‑3p to activate its coding gene FGF14, thereby impeding metastatic progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, FGF14‐AS2 suppresses tumor growth by sponging miR‑1288‑3p, which results in the upregulation of RERG and inactivation of Ras/ERK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in prostate carcinoma, FGF14‐AS2 downregulation lifts its inhibitory control on miR‑96‑5p, leading to decreased expression of the tumor suppressor AJAP1 and contributing to enhanced proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast to these tumor‐suppressive roles, evidence from glioma shows that FGF14‐AS2 is significantly upregulated and associated with poor patient survival, where its silencing inhibits tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, FGF14‐AS2 has also been identified as part of prognostic gene signatures in HBV‐related hepatocellular carcinoma, further suggesting its potential as a biomarker in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Taken together, FGF14‐AS2 appears to be a multifunctional lncRNA whose regulatory impact is mediated through ceRNA networks that modulate key oncogenic microRNAs and signaling pathways such as MAPK/ERK. Its differential expression in various cancers and its association with clinical parameters underscore its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Yang, N Xun, J-G Wu "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FGF14-AS2 represses proliferation, migration, invasion, and induces apoptosis in breast cancer by sponging miR-205-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201908_18737"}], "href": "https://doi.org/10.26355/eurrev_201908_18737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31486497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31486497"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fan Yang, Ye-Huan Liu, Si-Yang Dong, et al. 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