FHIP1A Gene

Name FHF complex subunit HOOK interacting protein 1A
Description Involved in protein localization to perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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Disruption of precise motor–cargo interactions can affect a wide range of processes—from cell cycle progression in hepatocellular carcinoma (1) to immune regulation and antiviral responses (4,6), as well as influencing other pathophysiological conditions (7,11). These findings collectively suggest that proteins like FHIP1A are critical mediators that fine‐tune the spatial and temporal aspects of intracellular vesicle trafficking and cytoskeletal organization, which are essential for maintaining normal cellular function and may have significant implications in disease.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", (11)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Quentin Bayard, Léa Meunier, Camille Peneau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07552-9"}], "href": "https://doi.org/10.1038/s41467-018-07552-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30531861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30531861"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arunakumar Gangaplara, Craig Martens, Eric Dahlstrom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1006985"}], "href": "https://doi.org/10.1371/journal.ppat.1006985"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29672594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29672594"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thomas O'Loughlin, Thomas A Masters, Folma Buss "}, {"type": "b", "children": [{"type": "t", "text": "The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201744884"}], "href": "https://doi.org/10.15252/embr.201744884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29467281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29467281"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "William B Redwine, Morgan E DeSantis, Ian Hollyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human cytoplasmic dynein interactome reveals novel activators of motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.28257"}], "href": "https://doi.org/10.7554/eLife.28257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28718761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28718761"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nagavalli Somasundaram, Jing Quan Lim, Choon Kiat Ong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-019-0717-6"}], "href": "https://doi.org/10.1186/s13045-019-0717-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30876435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30876435"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xinyuan Li, Haitao Yu, Zongjie Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Prognostic Model Based on Autophagy-Related Long Non-Coding RNAs for Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.711736"}], "href": "https://doi.org/10.3389/fonc.2021.711736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34414116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34414116"}]}]}]}
NCBI Gene ID 729830
API
Download Associations
Predicted Functions View FHIP1A's ARCHS4 Predicted Functions.
Co-expressed Genes View FHIP1A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View FHIP1A's ARCHS4 Predicted Functions.

Functional Associations

FHIP1A has 3,843 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 23 datasets.

Click the + buttons to view associations for FHIP1A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of FHIP1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with FHIP1A gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of FHIP1A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing FHIP1A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with FHIP1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving FHIP1A gene from the curated GO Biological Process Annotations2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of FHIP1A gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of FHIP1A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with FHIP1A gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
HuBMAP ASCT+B Annotations cell types associated with FHIP1A gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression cell types associated with FHIP1A gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with FHIP1A gene from the HuBMAP Azimuth Cell Type Annotations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by FHIP1A gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of FHIP1A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of FHIP1A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of FHIP1A gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of FHIP1A gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of FHIP1A gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of FHIP1A gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of FHIP1A gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FHIP1A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FHIP1A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with FHIP1A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.