{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated FHIP2A—also known as FAM160B1—in several fundamental biological processes. Mutations in FAM160B1 have been identified in individuals with syndromic intellectual disability, underscoring its essential role in nervous system development and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, a genetic variant (rs7099208) that reduces FAM160B1 expression in the testes has been associated with non‐obstructive azoospermia, pointing to an important role in spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Further extending its clinical relevance, higher expression levels of FAM160B1 in lung adenocarcinoma have been correlated with a favorable prognosis, suggesting that FAM160B1 may influence tumor biology through epigenetic interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings indicate that FHIP2A/FAM160B1 is a multifunctional protein involved in the maintenance of neuronal integrity, proper reproductive function, and potentially in modulating cancer outcomes, although its precise molecular mechanisms remain to be fully elucidated.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rezan Nehir Mavioğlu, Bülent Kara, Gür Akansel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13612"}], "href": "https://doi.org/10.1111/cge.13612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31353455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31353455"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Anazi, S Maddirevula, E Faqeih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2016.113"}], "href": "https://doi.org/10.1038/mp.2016.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27431290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27431290"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Zhang, Jing Qian, Minghui Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A susceptibility locus rs7099208 is associated with non-obstructive azoospermia via reduction in the expression of FAM160B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7555/JBR.29.20150034"}], "href": "https://doi.org/10.7555/JBR.29.20150034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26668583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26668583"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "H Liu, H Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Prognosis related miRNAs, DNA methylation, and epigenetic interactions in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2018_181029N805"}], "href": "https://doi.org/10.4149/neo_2018_181029N805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30868896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30868896"}]}]}]}