FHL2 Gene

Name	four and a half LIM domains 2
Description	This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Four‐and‐a‐half LIM domain protein 2 (FHL2) emerges from these studies as a multifaceted adaptor and co‐regulator that modulates diverse signaling pathways in normal physiology and disease. In the context of oncogenic signaling, FHL2 functions as a nuclear cofactor that associates with the intracellular domain of EpCAM to form a complex with β–catenin and LEF‐1, thereby driving cyclin D1 expression and promoting cell cycle progression and tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In prostate cancer cells, nuclear expression of FHL2 correlates with aggressive disease, acting as an androgen receptor coactivator and, through its interaction with FOXO1 and SIRT1, it dampens FOXO1‐mediated apoptotic signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In muscle and cardiac tissues, FHL2 modulates differentiation and mechanotransduction. It regulates β–catenin/TCF–dependent transcription in muscle by competing with the coactivator MAL/MRTF‐A, thus influencing smooth muscle gene expression and myogenic differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, FHL2 potentiates Wnt signaling by cooperating with β–catenin and the acetyltransferase CBP/p300 to activate target genes, including those involved in proliferation such as cyclin D1 and IL‐8"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its interaction with titin and integrins further suggests a role in stabilizing sarcomeric structures during muscle development and in mediating stretch‐based signaling – a mechanism also underscored by increased FHL2 expression coordinating antihypertrophic responses via inhibition of serum response factor and ERK in cardiomyocytes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FHL2 also promotes osteogenic differentiation by interacting with β–catenin to enhance its nuclear translocation and TCF/LEF–dependent transcription, leading to increased Runx2 expression and osteoblast marker activation; in parallel, its interaction with IGFBP–5 in osteoblasts implicates FHL2 as a mediator of bone formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond differentiation and proliferative cues, FHL2 participates in apoptotic and growth factor–dependent processes. Acting as DRAL, FHL2 is recruited by the dependence receptor Patched in the absence of Sonic hedgehog to form a caspase–activating complex that leads to caspase–9 activation and induction of apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In addition, FHL2 facilitates presenilin–2–dependent PDGF receptor expression, thereby modulating PI3K/Akt signaling under select conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In melanoma cells, an interplay between SKI, FHL2, and β–catenin further enhances transcription of genes that promote cell survival, proliferation, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, epigenetic analyses identify the FHL2 CpG island as one of the most age–correlated markers in blood, supporting its potential as a biomarker for biological age."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " In cardiac stretch–mediated signaling, mutations in genes encoding partners of FHL2 (such as CARP) underscore its importance in the regulation of mechanical stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, FHL2 serves as a versatile scaffold that integrates transcriptional coactivation, cytoskeletal dynamics, and mechanosensitive signaling across multiple tissues, highlighting its central role in cellular differentiation, proliferation, apoptosis, and tissue homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dorothea Maetzel, Sabine Denzel, Brigitte Mack, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear signalling by tumour-associated antigen EpCAM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1824"}], "href": "https://doi.org/10.1038/ncb1824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19136966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19136966"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Chaves-Pérez, B Mack, D Maetzel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EpCAM regulates cell cycle progression via control of cyclin D1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.75"}], "href": "https://doi.org/10.1038/onc.2012.75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22391566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22391566"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Philip Kahl, Lucia Gullotti, Lukas Carl Heukamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-1570"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-1570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17145880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17145880"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yonghua Yang, Huayan Hou, Edward M Haller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600570"}], "href": "https://doi.org/10.1038/sj.emboj.7600570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15692560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15692560"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ulrike Philippar, Gerhard Schratt, Christoph Dieterich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2004.11.039"}], "href": "https://doi.org/10.1016/j.molcel.2004.11.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15610731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15610731"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bernd Martin, Richard Schneider, Stefanie Janetzky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200202075"}], "href": "https://doi.org/10.1083/jcb.200202075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12370240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12370240"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Wei, Claire-Angélique Renard, Charlotte Labalette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the LIM protein FHL2 as a coactivator of beta-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M207216200"}], "href": "https://doi.org/10.1074/jbc.M207216200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12466281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12466281"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Charlotte Labalette, Claire-Angélique Renard, Christine Neuveut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.24.10689-10702.2004"}], "href": "https://doi.org/10.1128/MCB.24.24.10689-10702.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15572674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15572674"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ryuji Okamoto, Yuxin Li, Kensuke Noma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.12-217018"}], "href": "https://doi.org/10.1096/fj.12-217018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23271052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23271052"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Thomas Samson, Neil Smyth, Stefanie Janetzky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312894200"}], "href": "https://doi.org/10.1074/jbc.M312894200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117962"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zahia Hamidouche, Eric Haÿ, Pascal Vaudin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-106302"}], "href": "https://doi.org/10.1096/fj.08-106302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18653765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18653765"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yousef G Amaar, Garrett R Thompson, Thomas A Linkhart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110872200"}], "href": "https://doi.org/10.1074/jbc.M110872200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11821401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11821401"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Frédéric Mille, Chantal Thibert, Joanna Fombonne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1880"}], "href": "https://doi.org/10.1038/ncb1880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19465923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19465923"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "David E Kang, Il Sang Yoon, Emanuela Repetto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500833200"}], "href": "https://doi.org/10.1074/jbc.M500833200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16014629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16014629"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dahu Chen, Weidong Xu, Elise Bales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SKI activates Wnt/beta-catenin signaling in human melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14583455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14583455"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Paolo Garagnani, Maria G Bacalini, Chiara Pirazzini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of ELOVL2 gene as a new epigenetic marker of age."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12005"}], "href": "https://doi.org/10.1111/acel.12005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23061750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23061750"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mousumi Moulik, Matteo Vatta, Stephanie H Witt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2009.02.076"}], "href": "https://doi.org/10.1016/j.jacc.2009.02.076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19608030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19608030"}]}]}]}
Synonyms	FHL-2, AAG11, SLIM-3, SLIM3, DRAL
Proteins	FHL2_HUMAN
NCBI Gene ID	2274
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FHL2 has 12,731 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for FHL2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FHL2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FHL2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FHL2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FHL2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FHL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FHL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FHL2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FHL2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FHL2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FHL2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FHL2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FHL2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FHL2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FHL2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FHL2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FHL2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FHL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FHL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FHL2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FHL2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FHL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FHL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FHL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FHL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FHL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FHL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FHL2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FHL2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FHL2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FHL2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FHL2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FHL2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FHL2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FHL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FHL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FHL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FHL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FHL2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FHL2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FHL2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FHL2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.