HGNC Family | Tetratricopeptide repeat domain containing (TTC), Peptidylprolyl isomerases |
Name | FK506 binding protein 8, 38kDa |
Description | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FKBP8 (also known as FKBP38) is a multifunctional immunophilin that plays diverse roles in maintaining cellular homeostasis through its actions as an adaptor and co‐chaperone. In one well‐characterized function, FKBP8 binds to the mechanistic target of rapamycin (mTOR) and acts as an endogenous inhibitor of mTOR complex 1 activity; this inhibitory role is relieved by direct binding of active Rheb and by phosphatidic acid, although some studies have reported contrasting findings regarding FKBP8’s impact on mTOR signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 also contributes to mitochondrial quality control. By virtue of a conserved LC3‐interacting region in its N terminus, FKBP8 recruits ATG8/LC3 to the outer mitochondrial membrane, thereby facilitating mitochondrial fragmentation and promoting mitophagy under stressful conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, FKBP8 serves as an important host factor during viral infection. It specifically interacts with the hepatitis C virus nonstructural protein NS5A and forms a complex with Hsp90 to support viral RNA replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n As a co‐chaperone, FKBP8 is essential for the proper folding and trafficking of client proteins. For example, it regulates the maturation and surface expression of the HERG potassium channel, a process that is critical for normal cardiac electrophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 further influences apoptotic pathways by binding anti‐apoptotic proteins such as Bcl‑2 and Bcl‑X(L). The Rheb‐dependent modulation of this interaction ultimately affects the association of Bcl‑X(L) with pro‑apoptotic proteins, thereby contributing to cell survival under growth‐promoting conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the developing nervous system, FKBP8 has been shown to antagonize Sonic hedgehog signaling, thus ensuring proper neural patterning and preventing ectopic pathway activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, FKBP8 regulates hypoxia‐responsive pathways through its interaction with prolyl hydroxylase domain protein 2 (PHD2), thereby modulating the stability of hypoxia‐inducible factor (HIF) and downstream target gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 has also been implicated in cell size control, acting downstream of tuberous sclerosis complex (TSC) proteins, and its expression appears to inversely correlate with tumor invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, recent evidence indicates that FKBP8 functions as a co‐chaperone with HSP90 to facilitate the pre‐assembly of axonemal dynein motors, thereby playing a critical role in the formation of motile cilia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifunctional nature of FKBP8 in regulating key signaling pathways and cellular processes—including mTOR signaling, mitophagy, viral replication, protein trafficking, apoptosis, neural patterning, hypoxia responses, cell size control, and ciliary assembly—which may have important implications for development, tumor progression, and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaochun Bai, Dongzhu Ma, Anling Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1147379"}], "href": "https://doi.org/10.1126/science.1147379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17991864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17991864"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mee-Sup Yoon, Yuting Sun, Edwin Arauz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.262816"}], "href": "https://doi.org/10.1074/jbc.M111.262816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21737445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21737445"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dongzhu Ma, Xiaochun Bai, Shuguang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The switch I region of Rheb is critical for its interaction with FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802356200"}], "href": "https://doi.org/10.1074/jbc.M802356200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18658153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18658153"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xuemin Wang, Bruno D Fonseca, Hua Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803348200"}], "href": "https://doi.org/10.1074/jbc.M803348200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18676370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18676370"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zambarlal Bhujabal, Åsa B Birgisdottir, Eva Sjøttem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 recruits LC3A to mediate Parkin-independent mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201643147"}], "href": "https://doi.org/10.15252/embr.201643147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28381481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28381481"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hongxu Xian, Qiaoyun Yang, Lin Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10096-1"}], "href": "https://doi.org/10.1038/s41467-019-10096-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31053718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31053718"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Toru Okamoto, Yorihiro Nishimura, Tohru Ichimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601367"}], "href": "https://doi.org/10.1038/sj.emboj.7601367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17024179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17024179"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Valerie E Walker, Roxana Atanasiu, Hung Lam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-chaperone FKBP38 promotes HERG trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701006200"}], "href": "https://doi.org/10.1074/jbc.M701006200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17569659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17569659"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dongzhu Ma, Xiaochun Bai, Huafei Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.092353"}], "href": "https://doi.org/10.1074/jbc.M109.092353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20048149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20048149"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Oleg V Bulgakov, Jonathan T Eggenschwiler, Dong-Hyun Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01122"}], "href": "https://doi.org/10.1242/dev.01122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105374"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ahryon Cho, Hyuk W Ko, Jonathan T Eggenschwiler "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2008.05.558"}], "href": "https://doi.org/10.1016/j.ydbio.2008.05.558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18590716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18590716"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sandra Barth, Jutta Nesper, Philippe A Hasgall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01324-06"}], "href": "https://doi.org/10.1128/MCB.01324-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17353276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17353276"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sandra Barth, Frank Edlich, Utta Berchner-Pfannschmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.032631"}], "href": "https://doi.org/10.1074/jbc.M109.032631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546213"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Margit Rosner, Katja Hofer, Marion Kubista, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206776"}], "href": "https://doi.org/10.1038/sj.onc.1206776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12894220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12894220"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sylvia Fong, Leslie Mounkes, Yong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2332307100"}], "href": "https://doi.org/10.1073/pnas.2332307100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14612567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14612567"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Girish R Mali, Patricia L Yeyati, Seiya Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZMYND10 functions in a chaperone relay during axonemal dynein assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.34389"}], "href": "https://doi.org/10.7554/eLife.34389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29916806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29916806"}]}]}]}
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Synonyms | FKBPR38, FKBP38 |
Proteins | FKBP8_HUMAN |
NCBI Gene ID | 23770 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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FKBP8 has 6,884 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.
Click the + buttons to view associations for FKBP8 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of FKBP8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of FKBP8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of FKBP8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with FKBP8 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with FKBP8 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP8 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of FKBP8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of FKBP8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FKBP8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing FKBP8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing FKBP8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing FKBP8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing FKBP8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with FKBP8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with FKBP8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing FKBP8 protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of FKBP8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with FKBP8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with FKBP8 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with FKBP8 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of FKBP8 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by FKBP8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with FKBP8 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with FKBP8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with FKBP8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with FKBP8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with FKBP8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FKBP8 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of FKBP8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing FKBP8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with FKBP8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with FKBP8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing FKBP8 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of FKBP8 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving FKBP8 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving FKBP8 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving FKBP8 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing FKBP8 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing FKBP8 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by FKBP8 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by FKBP8 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by FKBP8 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of FKBP8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of FKBP8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for FKBP8 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of FKBP8 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of FKBP8 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for FKBP8 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with FKBP8 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for FKBP8 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of FKBP8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate FKBP8 protein from the curated KEA Substrates of Kinases dataset. | |
Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate FKBP8 protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FKBP8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of FKBP8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with FKBP8 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of FKBP8 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of FKBP8 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of FKBP8 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FKBP8 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing FKBP8 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain FKBP8 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by FKBP8 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting FKBP8 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of FKBP8 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by FKBP8 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of FKBP8 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of FKBP8 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for FKBP8 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of FKBP8 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of FKBP8 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving FKBP8 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving FKBP8 protein from the Wikipathways PFOCR 2024 dataset. | |
PID Pathways | pathways involving FKBP8 protein from the PID Pathways dataset. | |
ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of FKBP8 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
Reactome Pathways 2024 | pathways involving FKBP8 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FKBP8 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FKBP8 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FKBP8 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of FKBP8 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of FKBP8 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FKBP8 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of FKBP8 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of FKBP8 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with FKBP8 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of FKBP8 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of FKBP8 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of FKBP8 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of FKBP8 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of FKBP8 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of FKBP8 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of FKBP8 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with FKBP8 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with FKBP8 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
Virus MINT Protein-Viral Protein Interactions | interacting viral proteins for FKBP8 from the Virus MINT Protein-Viral Protein Interactions dataset. | |
Virus MINT Protein-Virus Interactions | viruses interacting with FKBP8 from the Virus MINT Protein-Virus Interactions dataset. | |
WikiPathways Pathways 2014 | pathways involving FKBP8 protein from the Wikipathways Pathways 2014 dataset. | |