FKBP8 Gene

HGNC Family	Tetratricopeptide repeat domain containing (TTC), Peptidylprolyl isomerases
Name	FK506 binding protein 8, 38kDa
Description	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FKBP8 (also known as FKBP38) is a multifunctional immunophilin that plays diverse roles in maintaining cellular homeostasis through its actions as an adaptor and co‐chaperone. In one well‐characterized function, FKBP8 binds to the mechanistic target of rapamycin (mTOR) and acts as an endogenous inhibitor of mTOR complex 1 activity; this inhibitory role is relieved by direct binding of active Rheb and by phosphatidic acid, although some studies have reported contrasting findings regarding FKBP8’s impact on mTOR signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 also contributes to mitochondrial quality control. By virtue of a conserved LC3‐interacting region in its N terminus, FKBP8 recruits ATG8/LC3 to the outer mitochondrial membrane, thereby facilitating mitochondrial fragmentation and promoting mitophagy under stressful conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, FKBP8 serves as an important host factor during viral infection. It specifically interacts with the hepatitis C virus nonstructural protein NS5A and forms a complex with Hsp90 to support viral RNA replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n As a co‐chaperone, FKBP8 is essential for the proper folding and trafficking of client proteins. For example, it regulates the maturation and surface expression of the HERG potassium channel, a process that is critical for normal cardiac electrophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 further influences apoptotic pathways by binding anti‐apoptotic proteins such as Bcl‑2 and Bcl‑X(L). The Rheb‐dependent modulation of this interaction ultimately affects the association of Bcl‑X(L) with pro‑apoptotic proteins, thereby contributing to cell survival under growth‐promoting conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the developing nervous system, FKBP8 has been shown to antagonize Sonic hedgehog signaling, thus ensuring proper neural patterning and preventing ectopic pathway activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, FKBP8 regulates hypoxia‐responsive pathways through its interaction with prolyl hydroxylase domain protein 2 (PHD2), thereby modulating the stability of hypoxia‐inducible factor (HIF) and downstream target gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FKBP8 has also been implicated in cell size control, acting downstream of tuberous sclerosis complex (TSC) proteins, and its expression appears to inversely correlate with tumor invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, recent evidence indicates that FKBP8 functions as a co‐chaperone with HSP90 to facilitate the pre‐assembly of axonemal dynein motors, thereby playing a critical role in the formation of motile cilia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifunctional nature of FKBP8 in regulating key signaling pathways and cellular processes—including mTOR signaling, mitophagy, viral replication, protein trafficking, apoptosis, neural patterning, hypoxia responses, cell size control, and ciliary assembly—which may have important implications for development, tumor progression, and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaochun Bai, Dongzhu Ma, Anling Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1147379"}], "href": "https://doi.org/10.1126/science.1147379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17991864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17991864"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mee-Sup Yoon, Yuting Sun, Edwin Arauz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.262816"}], "href": "https://doi.org/10.1074/jbc.M111.262816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21737445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21737445"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dongzhu Ma, Xiaochun Bai, Shuguang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The switch I region of Rheb is critical for its interaction with FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802356200"}], "href": "https://doi.org/10.1074/jbc.M802356200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18658153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18658153"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xuemin Wang, Bruno D Fonseca, Hua Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803348200"}], "href": "https://doi.org/10.1074/jbc.M803348200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18676370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18676370"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zambarlal Bhujabal, Åsa B Birgisdottir, Eva Sjøttem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 recruits LC3A to mediate Parkin-independent mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201643147"}], "href": "https://doi.org/10.15252/embr.201643147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28381481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28381481"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hongxu Xian, Qiaoyun Yang, Lin Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10096-1"}], "href": "https://doi.org/10.1038/s41467-019-10096-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31053718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31053718"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Toru Okamoto, Yorihiro Nishimura, Tohru Ichimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601367"}], "href": "https://doi.org/10.1038/sj.emboj.7601367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17024179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17024179"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Valerie E Walker, Roxana Atanasiu, Hung Lam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-chaperone FKBP38 promotes HERG trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701006200"}], "href": "https://doi.org/10.1074/jbc.M701006200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17569659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17569659"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dongzhu Ma, Xiaochun Bai, Huafei Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.092353"}], "href": "https://doi.org/10.1074/jbc.M109.092353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20048149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20048149"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Oleg V Bulgakov, Jonathan T Eggenschwiler, Dong-Hyun Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01122"}], "href": "https://doi.org/10.1242/dev.01122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105374"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ahryon Cho, Hyuk W Ko, Jonathan T Eggenschwiler "}, {"type": "b", "children": [{"type": "t", "text": "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2008.05.558"}], "href": "https://doi.org/10.1016/j.ydbio.2008.05.558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18590716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18590716"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sandra Barth, Jutta Nesper, Philippe A Hasgall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01324-06"}], "href": "https://doi.org/10.1128/MCB.01324-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17353276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17353276"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sandra Barth, Frank Edlich, Utta Berchner-Pfannschmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.032631"}], "href": "https://doi.org/10.1074/jbc.M109.032631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546213"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Margit Rosner, Katja Hofer, Marion Kubista, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206776"}], "href": "https://doi.org/10.1038/sj.onc.1206776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12894220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12894220"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sylvia Fong, Leslie Mounkes, Yong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2332307100"}], "href": "https://doi.org/10.1073/pnas.2332307100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14612567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14612567"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Girish R Mali, Patricia L Yeyati, Seiya Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZMYND10 functions in a chaperone relay during axonemal dynein assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.34389"}], "href": "https://doi.org/10.7554/eLife.34389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29916806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29916806"}]}]}]}
Synonyms	FKBPR38, FKBP38
Proteins	FKBP8_HUMAN
NCBI Gene ID	23770
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FKBP8 has 6,884 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for FKBP8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FKBP8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FKBP8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FKBP8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FKBP8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FKBP8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FKBP8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FKBP8 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FKBP8 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP8 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FKBP8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FKBP8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FKBP8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FKBP8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FKBP8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FKBP8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FKBP8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FKBP8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FKBP8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FKBP8 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FKBP8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FKBP8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FKBP8 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FKBP8 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FKBP8 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FKBP8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FKBP8 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FKBP8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FKBP8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FKBP8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FKBP8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FKBP8 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FKBP8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FKBP8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FKBP8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP8 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.