{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA FLG‐AS1 has emerged as a multifunctional regulatory molecule in a variety of disease contexts. In diabetic retinopathy, FLG‐AS1 acts as a competing endogenous RNA that sponges miR‐380‐3p to upregulate SOCS6 expression, thereby reducing inflammation, oxidative stress, and apoptosis in retinal epithelial cells and ultimately alleviating retinal injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In metabolic disorders such as obesity and type 2 diabetes mellitus, FLG‐AS1 has been identified as part of a competitive endogenous RNA network, suggesting that its dysregulation may serve as both a potential biomarker and a therapeutic target through its involvement in key metabolic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Its role in cancer is also becoming evident; FLG‐AS1 is recognized as a hub m6A‐modified lncRNA in low‐grade gliomas and contributes to a genomic instability‐associated prognostic signature, linking it to tumorigenesis and patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In neuropsychiatric conditions such as schizophrenia, FLG‐AS1 is implicated in ceRNA networks—specifically through its interaction with miR‐34a‐5p and the downstream target FOSL1—potentially influencing neurodevelopment and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, FLG‐AS1 has been incorporated into a three‐lncRNA classifier that predicts pathological complete response and favorable clinical outcomes in esophageal squamous cell carcinoma, and it is also differentially expressed in oral squamous cell carcinoma, highlighting its emerging value as a prognostic biomarker in diverse cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Luo, Lan Li, Fan Xiao, et al. 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