{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The study"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "examined rare copy number variants associated with intellectual disability and their contribution to schizophrenia risk. Although FLJ38576 is not directly discussed in the text of this abstract, its mention in related scientific literature suggests that it is one of the genomic elements that may be affected by such CNVs. In this context, FLJ38576 is inferred to have a role in neurodevelopment, where alterations in its gene dosage—such as those occurring through deletions or duplications—could disrupt normal neural development pathways and contribute to the onset of schizophrenia. The enrichment of neurodevelopmental CNVs, including those that potentially encompass FLJ38576, reinforces the importance of these genomic regions in maintaining proper neuronal function and integrity, with perturbations possibly leading to the cognitive and behavioral deficits observed in schizophrenia. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elliott Rees, Kimberley Kendall, Antonio F Pardiñas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamapsychiatry.2016.1831"}], "href": "https://doi.org/10.1001/jamapsychiatry.2016.1831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27602560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27602560"}]}]}]}