{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FLNB‐AS1 is a long non‐coding RNA implicated in diverse pathological contexts. In estrogen receptor–positive breast cancer—representing 70–75% of cases—it is suggested to modulate hormone receptor–related signaling pathways, thereby potentially influencing tumor behavior and patient response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, transcriptomic analyses in colon adenocarcinoma have identified FLNB‐AS1 as one of 15 pyroptosis‐related lncRNAs included in a prognostic risk signature. In this setting, its differential expression is associated with modulation of cell death pathways (pyroptosis) as well as alterations in the tumor immune microenvironment and overall patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Other genome‐wide studies in systemic sclerosis and investigations into ferroptosis‐related lncRNAs in cancers further underscore the broader relevance of lncRNAs as key regulators of cellular pathways that affect disease progression and therapeutic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although the precise mechanistic details of FLNB‐AS1 remain to be fully elucidated, its inclusion in these diverse studies suggests that FLNB‐AS1 may serve as a context‐dependent regulator—affecting hormone receptor signaling in breast cancer and influencing cell death and immune landscapes in colon adenocarcinoma—with potential implications as a biomarker or therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiulei Zhang, Shanjun Gao, Zhen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Analysis of Estrogen Receptor "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Promoting Tamoxifen Resistance-Related lncRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9031723"}], "href": "https://doi.org/10.1155/2020/9031723"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32420379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32420379"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fada Xia, Yuanliang Yan, Cong Shen "}, {"type": "b", "children": [{"type": "t", "text": "A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.811734"}], "href": "https://doi.org/10.3389/fcell.2021.811734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34966747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34966747"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elena López-Isac, Marialbert Acosta-Herrera, Martin Kerick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-12760-y"}], "href": "https://doi.org/10.1038/s41467-019-12760-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31672989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31672989"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Donglin Lai, Lin Tan, Xiaojia Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Ferroptosis-Related lncRNA Signatures Associated With Immunotherapy and Chemotherapy Responses in Patients With Stomach Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.798612"}], "href": "https://doi.org/10.3389/fgene.2021.798612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35047016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35047016"}]}]}]}