FMC1-LUC7L2 Gene

Name FMC1-LUC7L2 readthrough
Description This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LUC7L2 is an evolutionarily conserved pre‐mRNA splicing factor that belongs to the U1 snRNP complex and plays critical roles in 5′ splice site selection and alternative splicing regulation. In human cells, LUC7L2 influences multiple cellular pathways by modulating the splicing of key genes; for example, it alters the balance between oxidative phosphorylation and glycolysis by regulating splicing of metabolic enzymes such as PFKM and SLC7A11, thereby repressing mitochondrial respiration and promoting glycolytic activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LUC7L2 has been shown to control components of the innate immune response through a post‐transcriptional mechanism whereby it binds directly to intronic regions of transcripts such as that encoding MITA (STING). This binding impairs proper splicing, promotes nonsense-mediated decay, and thereby ultimately dampens antiviral signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, aberrations in LUC7L2—including mutation, deletion, or altered expression—have been frequently observed in various neoplasms. In myeloid malignancies, for instance, loss of LUC7L2 via deletion on chromosome 7q has been linked to adverse clinical outcomes, while in nasopharyngeal carcinoma, its overexpression contributes to radioresistance by affecting DNA replication and autophagy processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings demonstrate that LUC7L2 functions as a multifaceted regulator whose role in pre-mRNA splicing helps to reprogram cellular metabolism, modulate innate immune signaling, and impact tumor biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexis A Jourdain, Bridget E Begg, Eran Mick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.02.033"}], "href": "https://doi.org/10.1016/j.molcel.2021.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33852893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33852893"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Noah J Daniels, Courtney E Hershberger, Xiaorong Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.108989"}], "href": "https://doi.org/10.1016/j.celrep.2021.108989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33852859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33852859"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aaron A Hoskins, Timothy W Rhoads "}, {"type": "b", "children": [{"type": "t", "text": "When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.04.003"}], "href": "https://doi.org/10.1016/j.molcel.2021.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33961773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33961773"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chen Li, Lu Feng, Wei-Wei Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Discov (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41421-021-00277-y"}], "href": "https://doi.org/10.1038/s41421-021-00277-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34155193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34155193"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lin Shen, Chao Li, Fang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR/Cas9 genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-021-00783-8"}], "href": "https://doi.org/10.1038/s41420-021-00783-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34907164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34907164"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthew R M Jotte, Megan E McNerney "}, {"type": "b", "children": [{"type": "t", "text": "The significance of CUX1 and chromosome 7 in myeloid malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Hematol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MOH.0000000000000699"}], "href": "https://doi.org/10.1097/MOH.0000000000000699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35084368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35084368"}]}]}]}
NCBI Gene ID 100996928
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Download Associations
Predicted Functions View FMC1-LUC7L2's ARCHS4 Predicted Functions.
Co-expressed Genes View FMC1-LUC7L2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View FMC1-LUC7L2's ARCHS4 Predicted Functions.

Functional Associations

FMC1-LUC7L2 has 967 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for FMC1-LUC7L2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing FMC1-LUC7L2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with FMC1-LUC7L2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with FMC1-LUC7L2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving FMC1-LUC7L2 gene from the curated GO Biological Process Annotations2025 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with FMC1-LUC7L2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by FMC1-LUC7L2 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of FMC1-LUC7L2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of FMC1-LUC7L2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of FMC1-LUC7L2 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of FMC1-LUC7L2 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of FMC1-LUC7L2 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of FMC1-LUC7L2 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of FMC1-LUC7L2 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of FMC1-LUC7L2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of FMC1-LUC7L2 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FMC1-LUC7L2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FMC1-LUC7L2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with FMC1-LUC7L2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.