FOSB Gene

HGNC Family	Basic leucine zipper proteins
Name	FBJ murine osteosarcoma viral oncogene homolog B
Description	The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FOSB, and particularly its splice variant ΔFOSB, is a versatile component of the activator protein‐1 (AP‐1) transcription factor complex that mediates long‐term changes in gene expression in response to repeated or chronic stimuli. In the brain, repeated cocaine exposure leads to epigenetic modifications that repress histone methylation and stabilize ΔFOSB, thereby promoting structural and behavioral plasticity associated with addiction and reward sensitization"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " ΔFOSB accumulation is also implicated in the neural adaptations underlying depressive-like behavior, with its delayed expression in limbic regions correlating with sustained affective changes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In cardiac cells, FOSB partners with Jun family proteins such as JunB to form heterodimers that bind to AP‐1 sites and drive the transcription of genes like MMP‐2, a key contributor to extracellular matrix remodeling under hypoxic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in the context of neuroendocrine signaling, catecholamines can upregulate FOSB expression to drive interleukin‐8 production, which in turn enhances tumor growth and metastasis in ovarian carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " FOSB also functions in mesenchymal stem cells, where its induction by protein kinase A (PKA) serves as an early response that facilitates subsequent secretion of bone‐promoting cytokines and robust in vivo bone formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In vascular neoplasms, recurrent chromosomal translocations that result in SERPINE1–FOSB fusion transcripts have been identified as a pathognomonic event in pseudomyogenic hemangioendothelioma, underscoring a direct role for aberrant FOSB expression in oncogenic transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " In addition, preliminary genetic association studies suggest that allelic variants of FOSB may influence affiliative behaviors, potentially contributing to the etiology of autism spectrum disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", while in colorectal carcinoma, Reg IV-mediated activation of the EGF receptor/Akt pathway leads to increased FOSB expression and enhanced AP‐1 transcriptional activity that promotes the expression of genes linked to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ian Maze, Herbert E Covington, David M Dietz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role of the histone methyltransferase G9a in cocaine-induced plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1179438"}], "href": "https://doi.org/10.1126/science.1179438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20056891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20056891"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amir A Levine, Zhonghui Guan, Angel Barco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0509735102"}], "href": "https://doi.org/10.1073/pnas.0509735102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16380431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16380431"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eric J Nestler "}, {"type": "b", "children": [{"type": "t", "text": "∆FosB: a transcriptional regulator of stress and antidepressant responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2014.10.034"}], "href": "https://doi.org/10.1016/j.ejphar.2014.10.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25446562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25446562"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "François Frenois, Maïté Moreau, Jason O'Connor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychoneuroendocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.psyneuen.2007.03.005"}], "href": "https://doi.org/10.1016/j.psyneuen.2007.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17482371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17482371"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marina R Bergman, Sunfa Cheng, Norman Honbo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20020707"}], "href": "https://doi.org/10.1042/BJ20020707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12371906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12371906"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mian M K Shahzad, Jesusa M Arevalo, Guillermo N Armaiz-Pena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.109579"}], "href": "https://doi.org/10.1074/jbc.M110.109579"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20826776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20826776"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ramakrishnaiah Siddappa, Anton Martens, Joyce Doorn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0711190105"}], "href": "https://doi.org/10.1073/pnas.0711190105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18490653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18490653"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Charles Walther, Johnbosco Tayebwa, Henrik Lilljebjörn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4322"}], "href": "https://doi.org/10.1002/path.4322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24374978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24374978"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Guo Zhu, Ryma Benayed, Caleb Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-018-0175-7"}], "href": "https://doi.org/10.1038/s41379-018-0175-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30459475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30459475"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yin P Hung, Christopher D M Fletcher, Jason L Hornick "}, {"type": "b", "children": [{"type": "t", "text": "FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000000795"}], "href": "https://doi.org/10.1097/PAS.0000000000000795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28009608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28009608"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Carolyn M Yrigollen, Summer S Han, Anna Kochetkova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genes controlling affiliative behavior as candidate genes for autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2007.11.015"}], "href": "https://doi.org/10.1016/j.biopsych.2007.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18207134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18207134"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kumar S Bishnupuri, Qizhi Luo, Nabendu Murmu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2005.10.001"}], "href": "https://doi.org/10.1053/j.gastro.2005.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16401477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16401477"}]}]}]}
Synonyms	G0S3, GOS3, GOSB
Proteins	FOSB_HUMAN
NCBI Gene ID	2354
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FOSB has 14,335 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for FOSB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FOSB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FOSB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOSB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOSB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FOSB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FOSB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FOSB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOSB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FOSB protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FOSB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FOSB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FOSB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FOSB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FOSB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FOSB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FOSB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FOSB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FOSB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FOSB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FOSB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FOSB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FOSB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FOSB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FOSB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FOSB protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FOSB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FOSB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FOSB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FOSB gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FOSB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FOSB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FOSB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FOSB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FOSB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FOSB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FOSB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FOSB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FOSB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FOSB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FOSB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FOSB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.