{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FOXCUT is a long non‐coding RNA located immediately upstream of the FOXC1 gene that has emerged as an important regulator in multiple cancer types. In many tumors—including oral squamous cell carcinoma, esophageal squamous cell carcinoma, nasopharyngeal carcinoma, basal‐like or triple‐negative breast cancer, endometrial cancer, colorectal cancer, prostate cancer, and gastric adenocarcinoma—FOXCUT is markedly overexpressed, and its expression is strongly positively correlated with that of the transcription factor FOXC1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": " Functional studies consistently show that downregulation of FOXCUT leads to reduced FOXC1 expression along with significant inhibition of cell proliferation, migration, invasion, and epithelial–mesenchymal transition. These effects are accompanied by decreased levels of several key downstream factors including matrix metalloproteinases, vascular endothelial growth factor A, and interference with pro-growth signaling pathways such as PI3K/AKT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In contrast, in choroidal melanoma, FOXCUT is downregulated and—in conjunction with miR-296-3p—exerts tumor-suppressive effects by coordinately targeting MMP-2 and MMP-9."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these findings indicate that FOXCUT predominantly functions as an oncogenic long noncoding RNA through modulation of FOXC1, thereby promoting tumor progression and poor clinical outcomes. Its aberrant overexpression renders the FOXCUT/FOXC1 axis a promising prognostic biomarker and a potential therapeutic target in various malignancies. Moreover, interventions such as treatment with dendrosome curcumin that reduce FOXCUT expression highlight its potential for targeted cancer therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiang-pan Kong, Jie Yao, Wei Luo, et al. 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