{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nFOXF2, a mesenchymal transcription factor, plays a pivotal role in embryogenesis and tissue homeostasis. Its proper function is essential for craniofacial morphogenesis – with mutations linked to disorders of sex development and uvula anomalies, as well as for upper‐lip closure mediated by sonic hedgehog signaling – and for palatal development, where disruption can result in cleft lip. In addition, FOXF2 is specifically expressed in brain pericytes, where it regulates cerebrovascular maturation and the integrity of the blood–brain barrier, and it contributes to the proper development and coordinated functioning of the gastrointestinal tract."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncogenesis, FOXF2 exhibits context‐dependent functions that can be diametrically opposed. In several malignancies—including prostate, luminal‐type breast, colorectal, esophageal, hepatocellular, cervical, ovarian, and bladder cancers—loss or silencing of FOXF2 (often via promoter hypermethylation or repression by microRNAs such as miR-182 or miR-130a) is correlated with enhanced cell proliferation, invasion, and poorer patient prognosis. In contrast, in more aggressive subtypes such as basal-like breast cancer and pancreatic cancer, aberrantly maintained or even overexpressed FOXF2 can promote epithelial–mesenchymal transition, stemness, and osteomimetic differentiation, thereby driving metastasis to distant sites including bone and lymphatic vessels. These opposing effects are integrated within complex regulatory networks that include reciprocal transcriptional repression with FOXQ1, modulation by factors such as MAZ, TGF-β pathway components, and the RNA-binding protein MSI2, highlighting FOXF2’s dual role as both tumor suppressor and oncogenic regulator."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis and development, FOXF2 expression is finely tuned by diverse regulatory mechanisms—including epigenetic promoter methylation, regulation by non-coding RNAs (for example, competing endogenous RNAs such as ADAMTS9‐AS2) and microRNAs—and by genetic variants affecting enhancer activity. Notably, genome-wide association studies have identified stroke-associated single-nucleotide polymorphisms within FOXF2 regulatory regions, linking altered enhancer function to increased cerebrovascular risk. Moreover, in non-neoplastic fibrotic conditions such as intrauterine adhesions, FOXF2 interacts with Smad6 to modulate extracellular matrix gene transcription, underscoring its broader involvement in tissue remodeling and fibrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "U Jochumsen, R Werner, N Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of FOXF2 in patients with disorders of sex development (DSD) in combination with cleft palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sex Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000195679"}], "href": "https://doi.org/10.1159/000195679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19276632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19276632"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Azadeh Reyahi, Ali M Nik, Mozhgan Ghiami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2015.05.008"}], "href": "https://doi.org/10.1016/j.devcel.2015.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26120030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26120030"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lingxue Bu, Qianqian Chen, Hong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel evidence of association with nonsyndromic cleft lip with or without cleft palate was shown for single nucleotide polymorphisms in FOXF2 gene in an Asian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.23413"}], "href": "https://doi.org/10.1002/bdra.23413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26278207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26278207"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joshua L Everson, Dustin M Fink, Joon Won Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sonic hedgehog regulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Foxf2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.149930"}], "href": "https://doi.org/10.1242/dev.149930"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28506991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28506991"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Brian Paul Herring, April M Hoggatt, Anita Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogastroenterol Motil (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/nmo.13528"}], "href": "https://doi.org/10.1111/nmo.13528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30565344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30565344"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Leonie van der Heul-Nieuwenhuijsen, Natasja Dits, Wilfred Van Ijcken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The FOXF2 pathway in the human prostate stroma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.20996"}], "href": "https://doi.org/10.1002/pros.20996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19562724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19562724"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hiroshi Hirata, Koji Ueno, Varahram Shahryari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0055502"}], "href": "https://doi.org/10.1371/journal.pone.0055502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23383207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23383207"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Peng-Zhou Kong, Fan Yang, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased FOXF2 mRNA expression indicates early-onset metastasis and poor prognosis for breast cancer patients with histological grade II tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0061591"}], "href": "https://doi.org/10.1371/journal.pone.0061591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23620774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23620774"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yu Zhang, Xinying Wang, Zhongqiu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3833"}], "href": "https://doi.org/10.3892/or.2015.3833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25738520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25738520"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "S T Kundu, L A Byers, D H Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.71"}], "href": "https://doi.org/10.1038/onc.2015.71"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25798833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25798833"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong-Pan Tian, Shu-Min Lun, Huan-Jing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.636126"}], "href": "https://doi.org/10.1074/jbc.M114.636126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26070560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26070560"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Pang-Kuo Lo, Ji Shin Lee, Xiaohui Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2016.06.021"}], "href": "https://doi.org/10.1016/j.cellsig.2016.06.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27377963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27377963"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peng-Zhou Kong, Guang-Ming Li, Yin Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10876"}], "href": "https://doi.org/10.18632/oncotarget.10876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27487137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27487137"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiaoying Chen, Haochang Hu, Jing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 promoter methylation is associated with prognosis in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317692230"}], "href": "https://doi.org/10.1177/1010428317692230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28222662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28222662"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zi-Han Yu, Shu-Min Lun, Rui He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.05.020"}], "href": "https://doi.org/10.1016/j.canlet.2017.05.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28577976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28577976"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chunqing Dou, Xin Jin, Liyuan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 deficiency promotes hepatocellular carcinoma metastasis by inducing mesenchymal-epithelial transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-170139"}], "href": "https://doi.org/10.3233/CBM-170139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28582850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28582850"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wenzhong Chen, Kehui Tong, Jiren Yu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130a is upregulated in colorectal cancer and promotes cell growth and motility by directly targeting forkhead box F2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7257"}], "href": "https://doi.org/10.3892/mmr.2017.7257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849155"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Akira Higashimori, Yujuan Dong, Yanquan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-2403"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-2403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29374064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29374064"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jun Zhang, Chunxia Zhang, Lin Sang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 inhibits proliferation, migration, and invasion of Hela cells by regulating Wnt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20180747"}], "href": "https://doi.org/10.1042/BSR20180747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30249755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30249755"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Aihong Wang, Canhui Jin, Hongyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p/FOXF2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2018.09.179"}], "href": "https://doi.org/10.1016/j.ijbiomac.2018.09.179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30268751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30268751"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Li-Juan Kang, Zi-Han Yu, Jun Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal transrepression between FOXF2 and FOXQ1 controls basal-like breast cancer aggressiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201801916R"}], "href": "https://doi.org/10.1096/fj.201801916R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30807702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30807702"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Shuo Wang, Gui-Xi Li, Cong-Cong Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 reprograms breast cancer cells into bone metastasis seeds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10379-7"}], "href": "https://doi.org/10.1038/s41467-019-10379-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31222004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31222004"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ze Zhang, Chong Wang, Tiantian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-182-5p promotes human bladder cancer proliferation and migration through the FOXF2/SHH axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2021_210903N1266"}], "href": "https://doi.org/10.4149/neo_2021_210903N1266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35068163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35068163"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiao Zhang, Rui Zhang, Chen Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 oppositely regulates stemness in luminal and basal-like breast cancer cells through the Wnt/beta-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102082"}], "href": "https://doi.org/10.1016/j.jbc.2022.102082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35660418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35660418"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ting Li, Silin Huang, Wei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/15330338221118717"}], "href": "https://doi.org/10.1177/15330338221118717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35929169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35929169"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Deyong Jia, Zhicheng Zhou, Oh-Joon Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-34665-z"}], "href": "https://doi.org/10.1038/s41467-022-34665-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36369237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36369237"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Bang-Hua Zhong, Yu-Teng Ma, Jian Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor FOXF2 promotes the development and progression of pancreatic cancer by targeting MSI2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2024.8752"}], "href": "https://doi.org/10.3892/or.2024.8752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38847273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38847273"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lancet Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S1474-4422(16)00102-2"}], "href": "https://doi.org/10.1016/S1474-4422(16"}, {"type": "t", "text": "00102-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27068588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27068588"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Guobin Chen, Limin Liu, Jing Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved in the pathogenesis of intrauterine adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14708"}], "href": "https://doi.org/10.1111/jcmm.14708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32022446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32022446"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jae-Ryeon Ryu, Suchit Ahuja, Corey R Arnold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2121333119"}], "href": "https://doi.org/10.1073/pnas.2121333119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35994645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35994645"}]}]}]}