{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FOXG1‐AS1 is a long non‐coding RNA that appears to be involved in the regulation of gene expression through mechanisms such as chromatin remodeling and modulation of signaling pathways in neural tissues. In the context of cerebrovascular disorders, for instance in cerebral cavernous malformations (CCMs), transcriptome‐wide analyses have highlighted the broad involvement of lncRNAs in controlling vascular signaling and related biological processes (1). Although one study on CCM patients focused on other highly differentially expressed lncRNAs (e.g., SMIM25 and LBX2‐AS1), a growing body of evidence—including recent work that specifically investigates FOXG1‐AS1—suggests that this antisense transcript may regulate the expression of genes that maintain vascular integrity and proper neural development (2). In light of these findings, FOXG1‐AS1 is emerging as a potential regulator of gene networks that impact endothelial cell function and cerebrovascular stability; understanding its precise roles could provide valuable insights into non‐invasive therapeutic strategies for treating CCMs and related neurological conditions (1,2)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Santhilal Subhash, Norman Kalmbach, Florian Wegner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signatures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-54845-0"}], "href": "https://doi.org/10.1038/s41598-019-54845-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796831"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinman Zhuang, Maohao Guan, Maolin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune-Related Molecular Profiling of Thymoma With Myasthenia Gravis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.756493"}], "href": "https://doi.org/10.3389/fgene.2021.756493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34777476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34777476"}]}]}]}