{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies underscore the pivotal roles of long non‑coding RNAs (lncRNAs) in disease settings, with one study highlighting the potential prognostic value of FOXN3‑AS2 in lung adenocarcinoma. In the analysis of lung adenocarcinoma, a five‑lncRNA signature—including FOXN3‑AS2—was established through integrated RNA‐sequencing data and clinical survival information to stratify patients by risk of recurrence or metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, FOXN3‑AS2 is considered part of a prognostic marker panel whose target genes are enriched in key cellular processes such as cell receptor‑mediated signaling and cell adhesion, suggesting that aberrant expression of FOXN3‑AS2 may reflect underlying alterations in these pathways that contribute to tumor progression. In contrast, an independent study focused on medial temporal lobe epilepsy (MTLE) investigated differentially expressed lncRNAs—including those involved in transcriptional regulation and inflammatory signaling pathways—but did not report FOXN3‑AS2 among the highlighted transcripts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings suggest that while lncRNAs broadly regulate important biological processes in diverse diseases, FOXN3‑AS2 specifically may serve as a prognostic indicator in lung adenocarcinoma by participating in regulatory networks that modulate cell adhesion and receptor signaling.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianliang Li, Xiaoping Yu, Qian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of important lncRNAs associated with the prognosis of lung adenocarcinoma, based on integrated bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10061"}], "href": "https://doi.org/10.3892/mmr.2019.10061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30896819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30896819"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Song Qiao, Qi Xu, Lin Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Endocrinol Lett (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30183206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30183206"}]}]}]}