{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of ovarian cancer, FOXP1‐AS1—a long non‐coding RNA antisense to FOXP1—was found to be down‐regulated in patient serum samples compared to healthy controls."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This down‐regulation was observed alongside the targeting of FOXP1 by the up‐regulated microRNA hsa‑miR‑1181, suggesting that FOXP1‑AS1 may be involved in the regulatory network controlling FOXP1 expression, with potential implications for ovarian tumorigenesis. In contrast, an independent study characterizing hiPSC‐derived cardiomyocytes did not report on FOXP1‑AS1, focusing instead on single‑cell gene expression and electrophysiological maturation in cardiac lineages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these abstracts highlight FOXP1‑AS1 as a candidate factor in ovarian cancer where its altered expression might contribute to disease progression via miRNA‑mediated pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihong Ruan, Yuanyuan Xie, Fangmei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2018.01.006"}], "href": "https://doi.org/10.1016/j.ejogrb.2018.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29353130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29353130"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sherri M Biendarra-Tiegs, Xing Li, Dan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological Phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2019.0030"}], "href": "https://doi.org/10.1089/scd.2019.0030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30892143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30892143"}]}]}]}