{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FOXP1‐IT1 is a long non‐coding RNA (lncRNA) that has emerged as a potential regulator in cancer. In ovarian cancer, FOXP1‐IT1—as well as the related transcript FOXP1‐AS1—is found to be down‐regulated. This down‐regulation is observed in the context of dysregulated microRNA networks, where, for example, hsa‐miR‐1181 targets FOXP1, suggesting that reduced FOXP1‐IT1 expression may contribute to tumorigenesis by perturbing pathways such as the Jak‐STAT signaling pathway and other oncogenic mechanisms (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, high‐throughput expression profiling has identified FOXP1‐IT1 as one of several lncRNAs with differential expression. Specifically, FOXP1‐IT1 has been recognized as part of a panel of novel lncRNA signatures that distinguish tumor tissue from normal tissue and further serve as an independent prognostic biomarker for colon adenocarcinoma recurrence. These findings imply that FOXP1‐IT1 may be useful not only as a diagnostic marker but also as part of a prognostic prediction model in colorectal cancer (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although additional studies on the gene regulatory mechanisms of FOXP1 and other lncRNAs in distinct cellular contexts—such as immune cell differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and neuronal development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "—provide broader insights into non-coding RNA function, the studies outlined above specifically underscore the role of FOXP1‐IT1 in cancer. Collectively, these findings support a model in which FOXP1‐IT1 contributes to the complex regulatory networks that control oncogenic and tumor suppressor pathways, making it an attractive candidate for future diagnostic and prognostic applications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihong Ruan, Yuanyuan Xie, Fangmei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2018.01.006"}], "href": "https://doi.org/10.1016/j.ejogrb.2018.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29353130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29353130"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sepideh Chodary Khameneh, Sara Razi, Sara Shamdani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Weighted correlation network analysis revealed novel long non-coding RNAs for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-06934-w"}], "href": "https://doi.org/10.1038/s41598-022-06934-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35194111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35194111"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lipeng Jin, Chenyao Li, Tao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential prognostic prediction model of colon adenocarcinoma with recurrence based on prognostic lncRNA signatures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-020-00270-8"}], "href": "https://doi.org/10.1186/s40246-020-00270-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32522293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32522293"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Can Shi, Jessica Miley, Alison Nottingham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leukocyte integrin signaling regulates FOXP1 gene expression via FOXP1-IT1 long non-coding RNA-mediated IRAK1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2019.02.008"}], "href": "https://doi.org/10.1016/j.bbagrm.2019.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30831269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30831269"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kuan-Wei Chen, Jun-An Chen "}, {"type": "b", "children": [{"type": "t", "text": "Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12929-020-00628-z"}], "href": "https://doi.org/10.1186/s12929-020-00628-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32093746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32093746"}]}]}]}