{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FUT8‐AS1 is an emerging long non‐coding RNA that appears to play a role in disease pathogenesis by modulating key signaling networks. In gestational diabetes mellitus, FUT8‐AS1 was identified as part of a co‐expression network with TLR5 and GDF15, suggesting that it may influence inflammatory and metabolic pathways associated with the condition (1). In melanoma, analysis of The Cancer Genome Atlas data revealed that FUT8‐AS1 is downregulated, and its reduced expression is correlated with more aggressive clinical features and inferior overall survival; this points to a potential tumor‐suppressive role and prognostic value in melanoma (2). Collectively, these findings indicate that abnormal regulation of FUT8‐AS1 may contribute to disease progression in diverse pathological contexts, warranting further functional investigation."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Li, Die Hu, Yunhui Gong "}, {"type": "b", "children": [{"type": "t", "text": "Identification of potential lncRNAs and co-expressed mRNAs in gestational diabetes mellitus by RNA sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Matern Fetal Neonatal Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/14767058.2021.1875432"}], "href": "https://doi.org/10.1080/14767058.2021.1875432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33618585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33618585"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiang-Jun Chen, Sha Liu, Dong-Mei Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FUT8-AS1 Inhibits the Malignancy of Melanoma Through Promoting miR-145-5p Biogenesis and Suppressing NRAS/MAPK Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.586085"}], "href": "https://doi.org/10.3389/fonc.2020.586085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34094894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34094894"}]}]}]}