FXYD2 Gene

Name	FXYD domain containing ion transport regulator 2
Description	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FXYD2, the γ‐subunit of the Na,K‐ATPase, is a small membrane protein that plays a central role in fine tuning the enzyme’s transport kinetics and structural stability in several tissues—most notably in the kidney. In the distal convoluted tubule, FXYD2 is transcriptionally activated by renal transcription factors such as HNF1B and its co‐activators (for example, see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its expression in this segment is critical for proper magnesium reabsorption, and mutations (such as the p.Gly41Arg variant) lead to autosomal dominant hypomagnesemia with hypocalciuria."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Structural and mutagenesis studies have demonstrated that FXYD2 modulates Na,K‐ATPase kinetics—particularly affecting the pump’s affinity for Na+ and ATP—and contributes to its thermal stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its renal function, FXYD2 is expressed in other tissues including astrocytes and dorsal root ganglia. In astrocytes, increased cell surface presentation of FXYD2 is associated with glutamate uptake-dependent activation of Na,K‐ATPase, suggesting that it is part of a mechanism that couples excitatory neurotransmission to energy metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Likewise, its expression in specific subpopulations of sensory neurons hints at a role in modulating excitability and possibly pain signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic and immunohistochemical studies have further underscored the clinical relevance of FXYD2. In addition to its causative association with familial hypomagnesemia, differential expression levels of FXYD2 have been observed in various neoplasms. For instance, overexpression of FXYD2 in ovarian clear cell carcinoma, under transcriptional control by HNF1B, not only correlates with disease progression but also offers a potential therapeutic target via cardiac glycosides."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Moreover, FXYD2 expression patterns can serve as diagnostic markers in renal tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and gliomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", highlighting its broader significance in human disease. In pancreatic β‐cells, the absence of FXYD2 leads to enhanced Akt signaling and β‐cell hyperplasia, suggesting an additional role in regulating cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, alternative splice variants of FXYD2 have been identified, each with distinct extracellular domains that might contribute to tissue-specific regulation of Na,K‐ATPase activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Genetic studies also reveal that common variants in magnesium-regulating genes, including FXYD2, can influence systemic magnesium homeostasis and modify the risk of diabetes, likely by affecting Na,K‐ATPase activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Taken together, FXYD2 emerges as an essential regulator of Na,K‐ATPase function through its modulation of ion affinities and maintenance of enzyme stability. Its critical role in renal magnesium handling, neuronal excitability, and disease pathogenesis—ranging from genetic electrolyte disorders to cancer—highlights its potential as both a diagnostic marker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_fs", "start_ref": "2", "end_ref": "4"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shazia Adalat, Adrian S Woolf, Karen A Johnstone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HNF1B mutations associate with hypomagnesemia and renal magnesium wasting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2008060633"}], "href": "https://doi.org/10.1681/ASN.2008060633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19389850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19389850"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Silvia Ferrè, Gert Jan C Veenstra, Rianne Bouwmeester, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.11.108"}], "href": "https://doi.org/10.1016/j.bbrc.2010.11.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21130072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21130072"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Silvia Ferrè, Jeroen H F de Baaij, Patrick Ferreira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2013040337"}], "href": "https://doi.org/10.1681/ASN.2013040337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24204001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24204001"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeroen H F de Baaij, Eiske M Dorresteijn, Eric A M Hennekam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephrol Dial Transplant (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ndt/gfv014"}], "href": "https://doi.org/10.1093/ndt/gfv014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25765846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25765846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qun Sha, Wade Pearson, Lauren C Burcea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00519.2007"}], "href": "https://doi.org/10.1152/ajprenal.00519.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18448590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18448590"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "D Holstead Jones, Tony Y Li, Elena Arystarkhova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500697200"}], "href": "https://doi.org/10.1074/jbc.M500697200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15755730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15755730"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Athina Zouzoulas, Alex G Therien, Rosemarie Scanzano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of Na,K-ATPase by the gamma subunit: studies with transfected cells and transmembrane mimetic peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M308610200"}], "href": "https://doi.org/10.1074/jbc.M308610200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12907667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12907667"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao-Min Gong, Yi Ding, Jinghua Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2014.04.021"}], "href": "https://doi.org/10.1016/j.bbamem.2014.04.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24794573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24794573"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marina Gegelashvili, Anna Rodriguez-Kern, Luther Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2006.12.015"}], "href": "https://doi.org/10.1016/j.neuint.2006.12.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17316900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17316900"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Feng Wang, Bing Cai, Kai-Cheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FXYD2, a γ subunit of Na⁺, K⁺-ATPase, maintains persistent mechanical allodynia induced by inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2015.12"}], "href": "https://doi.org/10.1038/cr.2015.12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25633594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25633594"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Stéphanie Ventéo, Steeve Bourane, Ilana Méchaly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the Na,K-ATPase gamma-subunit FXYD2 by Runx1 and Ret signaling in normal and injured non-peptidergic nociceptive sensory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029852"}], "href": "https://doi.org/10.1371/journal.pone.0029852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22253804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22253804"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "I-Ling Hsu, Cheng-Yang Chou, Yi-Ying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7497"}], "href": "https://doi.org/10.18632/oncotarget.7497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26910837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26910837"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yi-Da Chung, Ting-Hang Liu, Yu-Ling Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated microfluidic platform for detection of ovarian clear cell carcinoma mRNA biomarker FXYD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Chip (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/d1lc00177a"}], "href": "https://doi.org/10.1039/d1lc00177a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34013940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34013940"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Joseph P Gaut, Dan L Crimmins, Christina M Lockwood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2012.202"}], "href": "https://doi.org/10.1038/modpathol.2012.202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23196795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23196795"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kaijia Zhou, Tao Jiang, Yanwei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-021-02476-2"}], "href": "https://doi.org/10.1186/s12883-021-02476-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34753441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34753441"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elena Arystarkhova, Yi B Liu, Cynthia Salazar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.401190"}], "href": "https://doi.org/10.1074/jbc.M112.401190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23344951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23344951"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "D H Jones, M C Golding, K J Barr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mouse Na+-K+-ATPase gamma-subunit gene (Fxyd2) encodes three developmentally regulated transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.2001.6.3.129"}], "href": "https://doi.org/10.1152/physiolgenomics.2001.6.3.129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11526196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11526196"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Chun-Yu Chang, Cheng-Hao Tang, Yi-Hong Hsin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Membr Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00232-013-9615-y"}], "href": "https://doi.org/10.1007/s00232-013-9615-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24258619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24258619"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Brenda C T Kieboom, Symen Ligthart, Abbas Dehghan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum magnesium and the risk of prediabetes: a population-based cohort study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-017-4224-4"}], "href": "https://doi.org/10.1007/s00125-017-4224-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28224192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28224192"}]}]}]}
Synonyms	HOMG2, ATP1G1
Proteins	ATNG_HUMAN
NCBI Gene ID	486
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FXYD2 has 6,562 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for FXYD2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FXYD2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FXYD2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FXYD2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FXYD2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FXYD2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FXYD2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FXYD2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FXYD2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FXYD2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FXYD2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FXYD2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FXYD2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FXYD2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FXYD2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FXYD2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FXYD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FXYD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FXYD2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FXYD2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FXYD2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FXYD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FXYD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FXYD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FXYD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FXYD2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FXYD2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FXYD2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FXYD2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FXYD2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for FXYD2 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FXYD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FXYD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FXYD2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FXYD2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FXYD2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FXYD2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FXYD2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FXYD2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FXYD2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FXYD2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FXYD2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.