{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs (lncRNAs) play diverse roles in regulating biological processes, with recent studies highlighting their contributions both in neuroregeneration and cancer biology. In the context of neural repair, a distinct lncRNA—not FZD10‐AS1 but Silc1—was found to be upregulated in regenerating peripheral neurons after sciatic nerve injury and to promote axonal outgrowth through cis‐activation of the transcription factor Sox11."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon cancer, in contrast, FZD10‐AS1 has emerged as a location‐specific lncRNA that is differentially expressed between right‐ and left‐sided tumors. Bioinformatic analyses integrating RNA sequencing data revealed that FZD10‐AS1 participates in a competing endogenous RNA (ceRNA) regulatory network, interacting with microRNAs and downstream target genes, and its expression level was significantly associated with overall patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " These findings suggest that while lncRNAs like Silc1 are central to regenerative transcriptional programs in the peripheral nervous system, FZD10‐AS1 is implicated in colon tumor biology and holds potential as a prognostic biomarker that can inform tailored treatment strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rotem Ben-Tov Perry, Hadas Hezroni, Micah Jonathan Goldrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Neuroregeneration by Long Noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2018.09.021"}], "href": "https://doi.org/10.1016/j.molcel.2018.09.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30401432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30401432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ke-Zhi Li, Yi-Xin Yin, Yan-Ping Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a long noncoding RNA-based competing endogenous RNA network and prognostic signatures of left- and right-side colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01901-3"}], "href": "https://doi.org/10.1186/s12935-021-01901-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33858429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33858429"}]}]}]}