GAB1 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH)
Name	GRB2-associated binding protein 1
Description	The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GAB1 is a multifunctional scaffolding protein that integrates and amplifies signals initiated by diverse receptor tyrosine kinases, thereby coordinating cell survival, proliferation, migration, and differentiation. For instance, in lung cancer, GAB1 mediates MET/hepatocyte growth factor (HGF)–induced drug resistance by linking receptor activation to the phosphatidylinositol 3‐kinase (PI3K)/Akt pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast tumor cells, the phosphorylation of GAB1—promoted via Rho kinase activity—is essential for recruiting PI3K and activating AKT signaling, which supports tumor cell growth, survival, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in non–small cell lung cancer, GAB1 participates in crosstalk between mu opioid receptors and growth factor receptor signaling that promotes epithelial–mesenchymal transition and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of viral infection, studies reveal that GAB1 forms part of multiprotein complexes that shift the signaling balance toward cell survival through enhanced PI3K–AKT activation, thereby contributing to hepatitis C virus persistence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Computational and experimental analyses further demonstrate that GAB1 amplifies PI3K/Akt activation and prolongs Ras/MAPK (extracellular signal–regulated kinase) signaling, ensuring sustained mitogenic and survival cues that are critical for oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In hematologic malignancies, the expression level of GAB1 is subject to microRNA regulation (e.g., by miR-150), which in turn influences receptor signaling cascades and affects disease outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In growth factor–specific contexts, the tyrosine phosphorylation status of GAB1 determines its association with PI3K and consequently modulates downstream Akt activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, GAB1 functions in normal physiology. It contributes to cardiac hypertrophy through gp130-mediated signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and is indispensable for epidermal growth factor (EGF) receptor–driven cell proliferation and transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Importantly, in the peripheral nervous system, conditional removal of GAB1 from Schwann cells leads to hypomyelination and aberrant Remak bundle formation, indicating its crucial role in transducing neuregulin-1 signals for proper myelination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish that GAB1 acts as a central nexus within multiple receptor-mediated signaling networks, modulating oncogenic processes, contributing to therapeutic resistance, and guiding essential developmental events. Targeting the GAB1 signaling axis may thus provide promising therapeutic avenues for a range of pathologic conditions and malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexa B Turke, Kreshnik Zejnullahu, Yi-Long Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.11.022"}], "href": "https://doi.org/10.1016/j.ccr.2009.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20129249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20129249"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lilly Y W Bourguignon, Patrick A Singleton, Hongbo Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301885200"}], "href": "https://doi.org/10.1074/jbc.M301885200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12748184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12748184"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Frances E Lennon, Tamara Mirzapoiazova, Bolot Mambetsariev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091577"}], "href": "https://doi.org/10.1371/journal.pone.0091577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24662916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24662916"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yupeng He, Haruhisa Nakao, Seng-Lai Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.76.18.9207-9217.2002"}], "href": "https://doi.org/10.1128/jvi.76.18.9207-9217.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12186904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12186904"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anatoly Kiyatkin, Edita Aksamitiene, Nick I Markevich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600482200"}], "href": "https://doi.org/10.1074/jbc.M600482200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16687399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16687399"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marek Mraz, Liguang Chen, Laura Z Rassenti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-09-527234"}], "href": "https://doi.org/10.1182/blood-2013-09-527234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24787006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24787006"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cheng Fang Yu, Zhen-Xiang Liu, Lloyd G Cantley "}, {"type": "b", "children": [{"type": "t", "text": "ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200732200"}], "href": "https://doi.org/10.1074/jbc.M200732200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11896055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11896055"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yoshikazu Nakaoka, Keigo Nishida, Yasushi Fujio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000085562.48906.4A"}], "href": "https://doi.org/10.1161/01.RES.0000085562.48906.4A"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12855672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12855672"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Satoru Yamasaki, Keigo Nishida, Yuichi Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206284"}], "href": "https://doi.org/10.1038/sj.onc.1206284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12629518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12629518"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoon Kyung Shin, So Young Jang, So Young Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4947-13.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.4947-13.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24872569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24872569"}]}]}]}
Synonyms	DFNB26
Proteins	GAB1_HUMAN
NCBI Gene ID	2549
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GAB1 has 7,243 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 115 datasets.

Click the + buttons to view associations for GAB1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GAB1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by GAB1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GAB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GAB1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GAB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GAB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GAB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GAB1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GAB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GAB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GAB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GAB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with GAB1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GAB1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GAB1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GAB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GAB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GAB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GAB1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GAB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GAB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	CORUM Protein Complexes	protein complexs containing GAB1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GAB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GAB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GAB1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GAB1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with GAB1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of GAB1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GAB1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate GAB1 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving GAB1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with GAB1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GAB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GAB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GAB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GAB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GAB1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GAB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GAB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GAB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with GAB1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.