{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GABPB1‐AS1 is a long non‐coding RNA that appears to modulate diverse cellular processes—particularly in stress responses and cancer progression—by acting as a competing endogenous RNA (ceRNA) to regulate downstream oncogenic pathways. For example, in human induced pluripotent stem cells, GABPB1‐AS1 is one of several lncRNAs that rapidly respond to chemical stresses and may serve as a surrogate indicator of cellular stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the human myometrium during term labor, it has been identified among key hubs within a regulatory network that includes transcription factors and other non‐coding RNAs, suggesting a role in the transformation of uterine cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, GABPB1‐AS1 is upregulated in multiple tumor types. In human papillomavirus 16‐positive cervical cancer, its elevated expression correlates with larger tumor size, lymph node metastasis, and advanced clinical stage. Functionally, GABPB1‐AS1 acts as a ceRNA by sponging miR‐519e‐5p, thereby de-repressing the oncogene Notch2 to promote cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in primary Sjögren’s syndrome, higher levels of GABPB1‐AS1 are positively associated with B cell percentages and immunoglobulin G levels, indicating a potential role in immune regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies have implicated GABPB1‐AS1 as an oncogenic factor in several other malignancies. In osteosarcoma, its silencing has been shown to reduce cellular proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In glioma, GABPB1‐AS1 promotes tumor growth and metastasis by competitively binding miR‐330, which in turn de-represses ZNF367 and activates cell cycle signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In pancreatic cancer, it is identified as one of the key lncRNAs associated with both tumor progression and patient survival, functioning within a broader ceRNA regulatory network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in cytogenetically normal acute myeloid leukemia, elevated GABPB1‐AS1 expression correlates with poorer overall survival and is being considered as a potential prognostic biomarker"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and its differential expression has also been proposed as a marker for prostate cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that GABPB1‐AS1 plays multifaceted roles in both normal stress response and the pathogenesis of diverse diseases—primarily by acting as a ceRNA that modulates the expression of key regulatory genes, thereby impacting cell proliferation, invasion, immune modulation, and overall disease progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hidenori Tani, Yasuko Onuma, Yuzuru Ito, et al. 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