{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA GACAT1 (gastric cancer‐associated transcript 1) has been implicated in multiple aspects of tumor biology in a context‐dependent manner. In tongue squamous cell carcinoma, breast cancer, non‐small cell lung cancer, and oral squamous cell carcinoma, GACAT1 is frequently overexpressed and functions as an oncogenic driver, where it promotes cell proliferation, migration, and epithelial–mesenchymal transition. Mechanistically, GACAT1 acts as a competing endogenous RNA by binding and sequestering distinct microRNAs (such as miR‑149, miR‑875‑3p, and miR‑422a), thereby modulating downstream targets including STON2, YY1, and others that are critical for cell cycle progression and metastasis (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In contrast, in the context of gastric cancer chemoresistance, GACAT1 expression is markedly reduced in doxorubicin‐ and vincristine‐resistant cells, and restoration of its expression alleviates drug resistance by inactivating the AKT/mTOR/S6K1 signaling cascade through upregulation of PTEN (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Thus, GACAT1 exhibits diverse, context‐dependent roles by either promoting oncogenic behaviors or enhancing chemosensitivity, and may serve as a novel biomarker and therapeutic target in various human malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xueling Wang, Zuode Gong, Long Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA GACAT1 induces tongue squamous cell carcinoma migration and proliferation via miR-149."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16690"}], "href": "https://doi.org/10.1111/jcmm.16690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34378327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34378327"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qinghua Wang, Jie Xue, Qingfang Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-chain non-coding RNA GACAT1 promotes development and progression of breast cancer by targeting microRNA-875-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2020.11260"}], "href": "https://doi.org/10.3892/ol.2020.11260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32194758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32194758"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Youqing Zhong, Hui Lin, Qi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of long non‑coding RNA GACAT1 suppresses proliferation and induces apoptosis of NSCLC cells by sponging microRNA‑422a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4826"}], "href": "https://doi.org/10.3892/ijmm.2020.4826"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33416153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33416153"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jingxin Chen, Xubin Chen, Liangbin Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203416"}], "href": "https://doi.org/10.18632/aging.203416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34460438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34460438"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hengxuan Ding, Junfeng Sun, Ruixin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retracted Article: Long non-coding RNA GACAT1 alleviates doxorubicin and vincristine resistance through a PTEN/AKT/mTOR/S6K1 regulatory pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RSC Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/c8ra10030f"}], "href": "https://doi.org/10.1039/c8ra10030f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35521206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35521206"}]}]}]}