{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGARIN1A appears to function as a pivotal facilitative glucose transporter that also acts as a “transceptor,” integrating extracellular glucose detection with intracellular metabolic signaling. In multiple tissues—from pancreatic β‐cells to extra‐pancreatic sites—it contributes to the maintenance of glucose homeostasis by coupling sugar transport to downstream regulatory events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the intestine, GARIN1A is central to sugar uptake and sensing. It mediates the absorption of dietary glucose and fructose under basal conditions and is rapidly recruited to the apical membrane following simple‐sugar meals, thereby facilitating bulk absorption. Moreover, its activity extends to the uptake of dehydroascorbate, suggesting that GARIN1A can affect vitamin C bioavailability as well. These features allow the intestine to adjust to nutritional loads effectively."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin pancreatic β‐cells, GARIN1A is essential for proper glucose sensing and the regulation of insulin secretion. Its membrane trafficking and localization—regulated, in part, by post‐translational modifications such as N‐glycan formation—ensure a stable presence at the cell surface, which is critical for glucose‐stimulated hormone release. Furthermore, its receptor function contributes to the regulation of incretin secretion, and perturbations in its expression or localization are associated with impaired insulin release and alterations in islet morphology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGARIN1A expressed in the central nervous system also contributes significantly to whole‐body energy balance. In neural circuits—including those associated with the hypothalamus and brainstem—it participates in glucosensing mechanisms that regulate feeding behavior, autonomic output, and even cerebral blood flow in response to changing glycemic levels. These central actions help coordinate neuroendocrine responses, including appropriate glucagon secretion, during both fasting and refeeding."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn liver, kidney, and developing embryos, GARIN1A plays a crucial role in controlling metabolic fluxes and tissue development. Its expression is tightly regulated during development, and aberrant function is linked to congenital malformations under hyperglycemic conditions. In the liver and kidney, alterations in GARIN1A levels can modulate glucose reabsorption and disposal, with implications for diabetic pathophysiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "27"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies reveal that the regulation and modulation of GARIN1A are influenced by diverse pharmacological and genetic interventions that alter its trafficking, degradation, and activity. Hormones such as leptin can modulate its expression, while drugs and mutations affecting associated proteins (including kinases and transport modulators) further underscore its potential as a therapeutic target in metabolic diseases. 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"}, {"type": "b", "children": [{"type": "t", "text": "Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Res Rev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dmrr.1246"}], "href": "https://doi.org/10.1002/dmrr.1246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22069254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22069254"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chang-Qing Xia, Pengcheng Zhang, Shiwu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0097694"}], "href": "https://doi.org/10.1371/journal.pone.0097694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24835010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24835010"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jin Hyuk Jung, Kumiko Iwabuchi, Zhihong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Embryonic Stem Cell Proliferation Stimulated By Altered Anabolic Metabolism From Glucose Transporter 2-Transported Glucosamine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep28452"}], "href": "https://doi.org/10.1038/srep28452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27311888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27311888"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "David Tarussio, Salima Metref, Pascal Seyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI69154"}], "href": "https://doi.org/10.1172/JCI69154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24334455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24334455"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sara Cuesta, Roman Kireev, Cruz García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Age (Dordr) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11357-012-9397-7"}], "href": "https://doi.org/10.1007/s11357-012-9397-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22411259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22411259"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Nell Marty, Michel Dallaporta, Marc Foretz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI26309"}], "href": "https://doi.org/10.1172/JCI26309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16322792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16322792"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Isabelle Bady, Nell Marty, Michel Dallaporta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.55.04.06.db05-1386"}], "href": "https://doi.org/10.2337/diabetes.55.04.06.db05-1386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16567520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16567520"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kavaljit H Chhabra, Jessica M Adams, Brian Fagel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db15-0804"}], "href": "https://doi.org/10.2337/db15-0804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26467632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26467632"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hongxia Lei, Frédéric Preitner, Gwenaël Labouèbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cereb Blood Flow Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0271678X18766743"}], "href": "https://doi.org/10.1177/0271678X18766743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29561214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29561214"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "M J Barahona, F Langlet, G Labouèbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-22489-2"}], "href": "https://doi.org/10.1038/s41598-022-22489-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36271117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36271117"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hiroyuki Umino, Kazuhiro Hasegawa, Hitoshi Minakuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-25054-y"}], "href": "https://doi.org/10.1038/s41598-018-25054-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29717156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29717156"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "R Li, B Thorens, M R Loeken "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-006-0579-7"}], "href": "https://doi.org/10.1007/s00125-006-0579-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17235524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17235524"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Sang-Ki Park, Volker H Haase, Randall S Johnson "}, {"type": "b", "children": [{"type": "t", "text": "von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17203215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17203215"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Agueda González-Rodriguez, Carmen Nevado, Fernando Escrivá, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00514.2007"}], "href": "https://doi.org/10.1152/ajpgi.00514.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18535291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18535291"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jin Hyuk Jung, Xiao Dan Wang, Mary R Loeken "}, {"type": "b", "children": [{"type": "t", "text": "Mouse embryonic stem cells established in physiological-glucose media express the high KM Glut2 glucose transporter expressed by normal embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5966/sctm.2013-0093"}], "href": "https://doi.org/10.5966/sctm.2013-0093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24167319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24167319"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "O Ahmed, C Pramfalk, M Pedrelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Liver Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dld.2018.12.007"}], "href": "https://doi.org/10.1016/j.dld.2018.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30630736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30630736"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yassine Sakar, Corinne Nazaret, Philippe Lettéron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007935"}], "href": "https://doi.org/10.1371/journal.pone.0007935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19956534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19956534"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Javairiah Fatima, Corey W Iqbal, Scott G Houghton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Surg (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11605-008-0776-4"}], "href": "https://doi.org/10.1007/s11605-008-0776-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19082670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19082670"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Emilie Stolarczyk, Maude Le Gall, Patrick Even, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of sugar detection by GLUT2 affects glucose homeostasis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0001288"}], "href": "https://doi.org/10.1371/journal.pone.0001288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18074013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18074013"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "N Gaudreault, D R L Scriven, E D W Moore "}, {"type": "b", "children": [{"type": "t", "text": "Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-004-1583-4"}], "href": "https://doi.org/10.1007/s00125-004-1583-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15662550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15662550"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000107529"}], "href": "https://doi.org/10.1159/000107529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17762172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17762172"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "S Kahraman, C Aydin, G O Elpek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/450128"}], "href": "https://doi.org/10.1155/2015/450128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25699277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25699277"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Fan Li, Wei Du, Hui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2020.134762"}], "href": "https://doi.org/10.1016/j.neulet.2020.134762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31954765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31954765"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mitsunori Fujino, Naoki Morito, Takuto Hayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.163306"}], "href": "https://doi.org/10.1172/jci.insight.163306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36787192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36787192"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Bin Xu, Ying Hu, Ya-Ting Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in Expression of Follicular Glucose Transporters May Be Involved in Ovarian Function Impairment during Diabetic Hyperglycemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Lab Sci (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31882430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31882430"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Siresha Bathina, Tumininu S Faniyan, Lauren Bainbridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Normal β-Cell "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Glut2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom13030540"}], "href": "https://doi.org/10.3390/biom13030540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36979475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36979475"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Maya Talantikite, Marion Berenguer, Teresa Gonzalez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The first intracellular loop of GLUT4 contains a retention motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.183525"}], "href": "https://doi.org/10.1242/jcs.183525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27122188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27122188"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Yanling Zhang, Xiaomei Jiang, Dongsong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-024-05694-7"}], "href": "https://doi.org/10.1186/s12967-024-05694-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39334386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39334386"}]}]}]}