{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GARIN1B (also known as FAM71F1) is a testis‐enriched protein that plays a critical role during spermatogenesis. Its primary function involves the precise regulation of vesicle trafficking during acrosome formation by binding the GTP‐bound active forms of the small GTPases RAB2A and RAB2B. This interaction serves to suppress excessive vesicle fusion, thereby ensuring the proper morphogenesis of the acrosome and ultimately male fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its essential role in acrosome biogenesis, GARIN1B has also been implicated in broader cellular and pathological contexts. For example, gene expression studies in cutaneous T-cell lymphoma have identified GARIN1B among a panel of candidate target genes of the tumor-suppressive microRNA miR-26, suggesting that its dysregulation might contribute to oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, comparative transcriptomic analyses in testicular biopsies from infertile men indicate that GARIN1B is significantly down-regulated in patients with nonobstructive azoospermia, underscoring its potential utility as a biomarker for the degree of spermatogenic impairment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in an independent context, GARIN1B has emerged from integrative analyses as one of several m6A-related genes in a prognostic risk model for lung squamous cell carcinoma, highlighting its possible role in modulating tumor biology and patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akane Morohoshi, Haruhiko Miyata, Yuki Oyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.199644"}], "href": "https://doi.org/10.1242/dev.199644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34714330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34714330"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuka Matsuda, Sho Ikeda, Fumito Abe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15296"}], "href": "https://doi.org/10.1111/cas.15296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35133054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35133054"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Agnieszka Malcher, Natalia Rozwadowska, Tomasz Stokowy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2013.07.1999"}], "href": "https://doi.org/10.1016/j.fertnstert.2013.07.1999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24012201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24012201"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Erna Jia, Na Ren, Bo Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and validation of a novel prognostic model for lung squamous cell cancer based on N6-methyladenosine-related genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-022-02509-1"}], "href": "https://doi.org/10.1186/s12957-022-02509-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35220962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35220962"}]}]}]}