{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GAS6‐AS1 is an antisense long non‐coding RNA (lncRNA) transcribed from a region adjacent to the GAS6 gene that plays a multifaceted, context‐dependent role in cancer. In several studies on non–small cell lung cancer and breast cancer, decreased expression of GAS6‐AS1 has been observed; such downregulation is correlated with aggressive phenotypes—including enhanced metastasis and advanced clinical stages—suggesting that, in these contexts, GAS6‐AS1 may function in a tumor‐suppressive manner by modulating its host gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in other malignancies such as gastric cancer, acute myeloid leukemia, and clear cell renal cell carcinoma, GAS6‐AS1 is often upregulated. In these settings, functional studies have demonstrated that elevated GAS6‐AS1 promotes cell proliferation, migration, invasion, and even metabolic reprogramming. Mechanistically, GAS6‐AS1 has been shown to regulate the expression of its cognate gene GAS6—often via formation of RNA–RNA duplexes—thereby enhancing downstream receptor tyrosine kinase (AXL) signaling and influencing cell cycle progression (for example, promoting S‐phase entry)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, in pediatric AML, GAS6‐AS1 exerts oncogenic effects by interfacing with a microRNA‐mediated axis (miR‑370‑3p/TSPAN3) to drive malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in clear cell renal cell carcinoma, GAS6‐AS1 overexpression has been linked with increased glycolysis and invasiveness through modulation of the AMPK/mTOR signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Notably, in papillary renal cell carcinoma, GAS6‐AS1 has also been implicated as part of a prognostic signature, where its expression may carry a protective connotation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the diverse functions of GAS6‐AS1—it can act as either an oncogenic driver or a tumor suppressor depending on the tumor type and cellular context. Its capability to regulate GAS6 expression and downstream signaling pathways, as well as to interact with microRNAs, contributes to its potential utility as a prognostic biomarker and therapeutic target across a spectrum of human cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liang Han, Rong Kong, Dan-Dan Yin, et al. 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