{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies of secretory pathway kinases have revealed a new paradigm in which extracellular phosphorylation acts as a critical regulator of diverse biological processes. Kinases such as Fam20C, a well‐characterized member of this group, phosphorylate secreted proteins involved not only in biomineralization of bones and teeth but also in the regulation of lipid homeostasis, cell migration, wound healing, and cell adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although none of the current abstracts mention GASK1B by name, the collective evidence supports that functionally related secretory kinases share similar roles. In the context of acute myocardial infarction, for example, up‐regulation of FAM20 family genes suggests that such kinases may contribute to the early stress response through modulation of extracellular substrates that affect lipid metabolism, inflammation, and tissue repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n By extrapolation, GASK1B—a kinase presumed to belong to this secretory pathway family—likely functions by phosphorylating multiple extracellular proteins at defined motifs, thereby “tuning” signaling events in the extracellular milieu. This regulation can orchestrate structural remodeling, mediate cell–cell communication, and potentially influence the progression of diverse pathologies. As secreted protein kinases are emerging as integral components of biologic regulation and disease development, further studies on GASK1B may unravel novel mechanisms linking extracellular phosphorylation to processes such as tissue repair, metabolic control, and even cancer progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vincent S Tagliabracci, Sandra E Wiley, Xiao Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Single Kinase Generates the Majority of the Secreted Phosphoproteome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.05.028"}], "href": "https://doi.org/10.1016/j.cell.2015.05.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26091039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26091039"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vincent S Tagliabracci, Lorenzo A Pinna, Jack E Dixon "}, {"type": "b", "children": [{"type": "t", "text": "Secreted protein kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Biochem Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tibs.2012.11.008"}], "href": "https://doi.org/10.1016/j.tibs.2012.11.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23276407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23276407"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marek Kiliszek, Beata Burzynska, Marcin Michalak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0050054"}], "href": "https://doi.org/10.1371/journal.pone.0050054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23185530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23185530"}]}]}]}