{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long noncoding RNA GATA2‐AS1 emerges as a multifunctional regulatory molecule whose role spans several disease contexts. In esophageal squamous cell carcinoma, GATA2‐AS1 is downregulated and acts as a tumor suppressor by sequestering miR‐940 to upregulate PTPN12, thereby restraining malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer, GATA2‐AS1 similarly suppresses cell proliferation by interacting with the transcription factor GATA1 at the promoter region of GATA2 and is itself repressed by MYC, implicating it in the control of oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a patient case with a duplication of the entire GATA2 locus, a paradoxical decrease in GATA2 messenger RNA and protein levels was observed in conjunction with a several‐fold increase in GATA2‐AS1 transcription, suggesting that elevated levels of this antisense RNA may contribute to the downregulation of its sense gene"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ").\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in malignancy, GATA2‐AS1 has been identified in transcriptomic analyses as part of co-expression networks in gestational diabetes mellitus, where it is linked with genes such as PQLC3 and KIAA2026"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "). In colorectal and rectal adenocarcinomas, GATA2‐AS1 appears among prognostic signatures and epigenetically upregulated long noncoding RNAs, implicating it in immune cell infiltration, methylation regulation, and overall disease outcome"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ").\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that GATA2‐AS1 modulates gene expression through diverse mechanisms—ranging from microRNA sponging and direct transcriptional regulation to participation in epigenetic and co-expression networks—thereby influencing cellular proliferation, differentiation, and immune responses across both cancerous and metabolic diseases. This multifaceted role makes GATA2‐AS1 a promising target for therapeutic intervention and a potential biomarker for disease prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yunfeng Niu, Yanli Guo, Yan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2022.113130"}], "href": "https://doi.org/10.1016/j.yexcr.2022.113130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35364057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35364057"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Zhang, L Gao, M Shao, et al. 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