{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA GATA3‑AS1 has emerged as a multifunctional regulatory molecule with diverse roles in cancer and other physiological processes. In triple‐negative breast cancer, GATA3‑AS1 is markedly overexpressed and contributes to tumor progression and immune evasion by promoting the deubiquitination and stabilization of PD‑L1, while simultaneously facilitating the ubiquitination‐mediated degradation of GATA3, thereby impairing anti‐tumor immunity and enhancing cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in pancreatic cancer, upregulation of GATA3‑AS1 promotes cell viability, proliferation, invasion, and stemness, with its silencing leading to significant reductions in these malignant properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer patients undergoing neoadjuvant chemotherapy, high levels of GATA3‑AS1 have been identified as an independent predictive biomarker of nonresponse, underscoring its clinical utility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma, elevated GATA3‑AS1 expression is associated with aggressive tumor features, while its knockdown restores tumor‐suppressive gene expression and impairs cancer cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond solid tumors, aberrant hypermethylation of the GATA3‑AS1 promoter in chorionic villi from trisomy 16 miscarriages correlates with reduced GATA3 protein expression, suggesting a role in placental development and trophoblast differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, a genetic variant near GATA3‑AS1 has been implicated in modulating the perception and liking of dietary fat, highlighting its potential involvement in broader physiological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, elevated expression of GATA3‑AS1 in placental tissues has also been shown to have prognostic value in early‐onset preeclampsia, further emphasizing its multifaceted regulatory role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ming Zhang, Ning Wang, Peng Song, et al. 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