GBP1 Gene

Name	guanylate binding protein 1, interferon-inducible
Description	Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Interferon‐γ–inducible human guanylate-binding protein 1 (GBP1) is a large dynamin‐related GTPase that plays multiple, critical roles in cell‐autonomous host defenses. Biochemical studies have demonstrated that GBP1 engages in nucleotide‐dependent oligomerization and a unique, two‐step GTP hydrolysis reaction that underlies its activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In immune cells such as macrophages, GBP1 is robustly induced by interferons and acts as an intracellular sensor to target invading pathogens. It localizes to microbial vacuoles containing Gram‐negative bacteria and parasites—such as Salmonella and Toxoplasma gondii—where it binds lipopolysaccharide (LPS) with high affinity, promoting the recruitment and activation of effector molecules (for example, caspase‐4) that trigger inflammasome signaling, pyroptosis, or apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": " In human macrophages, GBP1 (often together with its close homologs) also mediates resistance against intracellular bacteria such as Chlamydia by rerouting bacterial inclusions toward lysosomal degradation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, GBP1 directly binds LPS and, through protein polymerization, acts like a surfactant that destabilizes the bacterial outer membrane to unmask lipid A, thereby enhancing antibacterial responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Antiviral studies further reveal that GBP1 restricts influenza virus replication—as well as that of other viruses—by mechanisms that depend on its GTP‐binding domain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its antimicrobial activities, GBP1 is expressed in nonimmune cells such as vascular endothelial cells where it mediates the anti‐proliferative and anti‐angiogenic effects of inflammatory cytokines by, for example, selectively repressing matrix metalloproteinase‐1 expression and inhibiting capillary tube formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In the context of cancer, GBP1 is frequently upregulated as part of interferon‐regulated gene signatures; its expression has been linked both to tumor-suppressive functions—by limiting cell invasion and proliferation in colorectal carcinoma and glioblastoma—and, in some settings, to adverse clinical outcomes via interactions with cytoskeletal regulatory pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": " Notably, several microbial pathogens have evolved strategies to counter GBP1‐mediated immunity; for example, Shigella flexneri deploys the type III secretion effector IpaH9.8 to induce ubiquitination and proteasomal degradation of GBP1, thereby enhancing bacterial survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, studies examining the intracellular targeting of interferon-inducible GTPases have shown that GBP1—along with related proteins—can be recruited to pathogen‐containing vacuoles via LC3 conjugation systems, emphasizing its central role as both a sensor and effector in innate immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings illustrate that GBP1 functions as a multifaceted immune effector that integrates interferon signaling to recognize and disrupt intracellular pathogens, regulate programmed cell death, and modulate inflammatory as well as neoplastic processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Agnidipta Ghosh, Gerrit J K Praefcke, Louis Renault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04510"}], "href": "https://doi.org/10.1038/nature04510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16511497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16511497"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bae-Hoon Kim, Avinash R Shenoy, Pradeep Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1201711"}], "href": "https://doi.org/10.1126/science.1201711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21551061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21551061"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-16889-z"}], "href": "https://doi.org/10.1038/s41467-020-16889-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32581219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32581219"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daniel Fisch, Hironori Bando, Barbara Clough, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2018100926"}], "href": "https://doi.org/10.15252/embj.2018100926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31268602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31268602"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elizabeth M Selleck, Sarah J Fentress, Wandy L Beatty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003320"}], "href": "https://doi.org/10.1371/journal.ppat.1003320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23633952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23633952"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Munir A Al-Zeer, Hesham M Al-Younes, Daniel Lauster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.22482"}], "href": "https://doi.org/10.4161/auto.22482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23086406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23086406"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miriam Kutsch, Linda Sistemich, Cammie F Lesser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2020104926"}], "href": "https://doi.org/10.15252/embj.2020104926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32510692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32510692"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alexandra Nordmann, Ludmilla Wixler, Yvonne Boergeling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-189886"}], "href": "https://doi.org/10.1096/fj.11-189886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22106366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22106366"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C C Carter, V Y Gorbacheva, D J Vestal "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Virol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00705-004-0489-2"}], "href": "https://doi.org/10.1007/s00705-004-0489-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15717119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15717119"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "E Guenzi, K Töpolt, E Cornali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/20.20.5568"}], "href": "https://doi.org/10.1093/emboj/20.20.5568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11598000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11598000"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Clara Lubeseder-Martellato, Eric Guenzi, Anita Jörg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)64452-5"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "64452-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12414522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12414522"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Elisabeth Naschberger, Roland S Croner, Susanne Merkel, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M112.019984"}], "href": "https://doi.org/10.1074/mcp.M112.019984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22964225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22964225"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marta De Donato, Marisa Mariani, Lella Petrella, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature24467"}], "href": "https://doi.org/10.1038/nature24467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29144452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29144452"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Anthony S Piro, Dulcemaria Hernandez, Sarah Luoma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of Cytosolic "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Shigella flexneri"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.01979-17"}], "href": "https://doi.org/10.1128/mBio.01979-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29233899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29233899"}]}]}]}
Proteins	GBP1_HUMAN
NCBI Gene ID	2633
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GBP1 has 9,072 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for GBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GBP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GBP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GBP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of GBP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GBP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with GBP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with GBP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of GBP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with GBP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing GBP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of GBP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.