HGNC Family | G protein-coupled receptors |
Name | growth hormone secretagogue receptor |
Description | This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The growth hormone secretagogue receptor (GHSR) is a multifunctional G‐protein–coupled receptor whose actions extend well beyond the well‐documented regulation of growth hormone secretion and food intake. In the central nervous system, GHSR is highly expressed in key hypothalamic neurons such as those co‐expressing neuropeptide Y and agouti‐related protein, where it regulates mitochondrial function, neuronal activation, and synaptic plasticity to promote orexigenic behavior and growth hormone pulsatility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In peripheral tissues, activation of GHSR by ghrelin has been shown to couple metabolic signals with endocrine responses by regulating insulin, glucagon, and lipogenic pathways in hepatocytes and adipocytes. Such actions not only drive pancreatic hormone release and adipocyte proliferation but also promote lipogenesis, thereby coordinating nutrient availability with energy storage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": " Furthermore, GHSR exhibits unusually high ligand‐independent (constitutive) activity that is critical for normal physiological processes; mutations that selectively impair this basal signaling have been linked to growth failure and metabolic dysregulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": " GHSR signaling is further modulated by its ability to form heterodimers with other receptors—including dopamine 1, melanocortin 3, and 5-HT2C receptors—which can finely tune downstream effector pathways involved in appetite regulation and reward processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": " In addition to its metabolic and neuroendocrine roles, GHSR activation in immune cells dampens proinflammatory cytokine production and thereby contributes to the regulation of inflammatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Finally, endogenous modulators such as liver‐expressed antimicrobial peptide 2 (LEAP2) interact with GHSR to antagonize ghrelin’s actions and refine receptor signaling in accordance with the nutritional state."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": " Collectively, these findings demonstrate that GHSR functions as a central integrator of endocrine, metabolic, and immunological signals. Its diverse roles in both the central nervous system and peripheral tissues highlight its promise as a therapeutic target for metabolic diseases, growth disorders, and inflammatory conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vishwa Deep Dixit, Eric M Schaffer, Robert S Pyle, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07181"}], "href": "https://doi.org/10.1038/nature07181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18668043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18668043"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuxiang Sun, Pei Wang, Hui Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0305930101"}], "href": "https://doi.org/10.1073/pnas.0305930101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15070777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15070777"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeffrey M Zigman, Yoshihide Nakano, Roberto Coppari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking ghrelin receptors resist the development of diet-induced obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI26002"}], "href": "https://doi.org/10.1172/JCI26002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16322794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16322794"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masahiro Murata, Yasuhiko Okimura, Keiji Iida, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db06-0878"}], "href": "https://doi.org/10.2337/db06-0878"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17130496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17130496"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min Seon Kim, Cho Ya Yoon, Pil Geum Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2003-0459"}], "href": "https://doi.org/10.1210/me.2003-0459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15178745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15178745"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Katsuya Dezaki, Masafumi Kakei, Toshihiko Yada "}, {"type": "b", "children": [{"type": "t", "text": "Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db07-0345"}], "href": "https://doi.org/10.2337/db07-0345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17575083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17575083"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jen-Chieh Chuang, Ichiro Sakata, Daisuke Kohno, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1411571111"}], "href": "https://doi.org/10.1073/pnas.1411571111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25157160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25157160"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Birgitte Holst, Adam Cygankiewicz, Tine Halkjaer Jensen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.064725"}], "href": "https://doi.org/10.1074/jbc.M109.064725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19920139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19920139"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Birgitte Holst, Thue W Schwartz "}, {"type": "b", "children": [{"type": "t", "text": "Ghrelin receptor mutations--too little height and too much hunger."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27999"}], "href": "https://doi.org/10.1172/JCI27999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16511600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16511600"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hong Jiang, Lorena Betancourt, Roy G Smith "}, {"type": "b", "children": [{"type": "t", "text": "Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0084"}], "href": "https://doi.org/10.1210/me.2005-0084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16601073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16601073"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Po-Ki Leung, Kevin B S Chow, Pui-Ngan Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2006.11.011"}], "href": "https://doi.org/10.1016/j.cellsig.2006.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17229547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17229547"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Koji Takahashi, Chiyuki Furukawa, Atsushi Takano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-1349"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-1349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17018595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17018595"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Harriët Schellekens, Wesley E P A van Oeffelen, Timothy G Dinan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.382473"}], "href": "https://doi.org/10.1074/jbc.M112.382473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23161547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23161547"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Anne Rediger, Carolin L Piechowski, Chun-Xia Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.287607"}], "href": "https://doi.org/10.1074/jbc.M111.287607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21940628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21940628"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dolgor Baatar, Kalpesh Patel, Dennis D Taub "}, {"type": "b", "children": [{"type": "t", "text": "The effects of ghrelin on inflammation and the immune system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2011.04.019"}], "href": "https://doi.org/10.1016/j.mce.2011.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21565248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21565248"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xuecai Ge, Hong Yang, Maria A Bednarek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2017.10.016"}], "href": "https://doi.org/10.1016/j.cmet.2017.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29233536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29233536"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Bharath K Mani, Nancy Puzziferri, Zhenyan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LEAP2 changes with body mass and food intake in humans and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI125332"}], "href": "https://doi.org/10.1172/JCI125332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31424424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31424424"}]}]}]}
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Synonyms | GHDP |
Proteins | GHSR_HUMAN |
NCBI Gene ID | 2693 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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GHSR has 4,673 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 102 datasets.
Click the + buttons to view associations for GHSR from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by GHSR gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of GHSR gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of GHSR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of GHSR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of GHSR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of GHSR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GHSR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GHSR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of GHSR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of GHSR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with GHSR gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GHSR gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of GHSR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of GHSR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
ClinVar Gene-Phenotype Associations | phenotypes associated with GHSR gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing GHSR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing GHSR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with GHSR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with GHSR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of GHSR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with GHSR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with GHSR gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with GHSR gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by GHSR gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with GHSR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with GHSR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with GHSR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with GHSR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with GHSR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with GHSR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for GHSR protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GHSR gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GHSR gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of GHSR gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing GHSR from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with GHSR gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with GHSR gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of GHSR gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with GHSR gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing GHSR from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of GHSR gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving GHSR gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving GHSR gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving GHSR gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing GHSR protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing GHSR protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing GHSR protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by GHSR gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by GHSR gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by GHSR gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of GHSR gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of GHSR gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding GHSR receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding GHSR receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
GWAS Catalog SNP-Phenotype Associations | phenotypes associated with GHSR gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
GWASdb SNP-Disease Associations | diseases associated with GHSR gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with GHSR gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of GHSR gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of GHSR protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPO Gene-Disease Associations | phenotypes associated with GHSR gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with GHSR gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for GHSR protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of GHSR gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving GHSR protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of GHSR gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of GHSR gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of GHSR gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain GHSR protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by GHSR gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting GHSR gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of GHSR gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by GHSR gene mutations from the MPO Gene-Phenotype Associations dataset. | |
NURSA Protein Complexes | protein complexs containing GHSR protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with GHSR gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for GHSR from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GHSR gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of GHSR gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving GHSR protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving GHSR protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2014 | pathways involving GHSR protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving GHSR protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of GHSR gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GHSR gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of GHSR gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of GHSR gene from the RummaGEO Gene Perturbation Signatures dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with GHSR gene from the SynGO Synaptic Gene Annotations dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of GHSR gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of GHSR gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of GHSR gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of GHSR gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of GHSR protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of GHSR protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of GHSR protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with GHSR protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with GHSR protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving GHSR protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving GHSR protein from the WikiPathways Pathways 2024 dataset. | |