| HGNC Family | G protein-coupled receptors |
| Name | G protein-coupled receptor, class C, group 6, member A |
| Description | Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GPRC6A is a multifunctional family C G‐protein–coupled receptor that functions as a broad extracellular sensor integrating diverse chemical signals—including basic amino acids, extracellular cations (such as Ca²⁺), osteocalcin, and testosterone—to regulate multiple physiological processes. For example, increased extracellular calcium can trigger the receptor’s signaling through phosphatidylinositol and Ca²⁺ pathways to promote NLRP3 inflammasome assembly in monocytes and macrophages, thereby amplifying inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In metabolic tissues, GPRC6A activation in pancreatic β‐cells enhances cell proliferation and insulin secretion and in intestinal L‐cells it mediates amino acid–stimulated GLP‑1 release, thereby contributing to glucose homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the reproductive system, osteocalcin binding to GPRC6A in Leydig cells promotes testosterone biosynthesis and supports germ cell survival, establishing a bone–testis endocrine axis that underlies male fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, the receptor mediates rapid, non‑genomic responses to testosterone in various tissues, including prostate cancer cells and even keratinocytes, linking it to both normal androgen signaling and pathological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, particularly prostate cancer, GPRC6A is overexpressed and has been implicated in activating proliferative and migratory signaling cascades (via ERK, AKT, and mTOR pathways) that promote tumor progression; in addition, specific genetic variants in GPRC6A have been associated with altered cancer risk and metabolic syndrome features."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging evidence indicates that GPRC6A is also expressed in specialized immune cells, such as colonic group 3 innate lymphoid cells, where its activation by ligands like L‑arginine promotes IL‑22 secretion via mTORC1 signaling—thereby contributing to mucosal healing during colonic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, current studies support a model in which GPRC6A acts as an integrative sensor that modulates inflammatory responses, energy metabolism, reproductive hormone biosynthesis, and cancer progression. Its ability to respond to multiple ligands positions it as a potentially valuable therapeutic target in metabolic disorders, male infertility, and prostate cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Manuela Rossol, Matthias Pierer, Nora Raulien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2339"}], "href": "https://doi.org/10.1038/ncomms2339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23271661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23271661"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Akiko Mizokami, Yu Yasutake, Jing Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0057375"}], "href": "https://doi.org/10.1371/journal.pone.0057375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23437377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23437377"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Manami Oya, Tetsuya Kitaguchi, Ramona Pais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.402677"}], "href": "https://doi.org/10.1074/jbc.M112.402677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23269670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23269670"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Franck Oury, Mathieu Ferron, Wang Huizhen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI65952"}], "href": "https://doi.org/10.1172/JCI65952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23728177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23728177"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jianwen Wei, Timothy Hanna, Nina Suda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db13-0887"}], "href": "https://doi.org/10.2337/db13-0887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24009262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24009262"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Pi, Abby L Parrill, L Darryl Quarles "}, {"type": "b", "children": [{"type": "t", "text": "GPRC6A mediates the non-genomic effects of steroids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.158063"}], "href": "https://doi.org/10.1074/jbc.M110.158063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20947496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20947496"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eunbi Ko, Hyun Choi, Borim Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.583450"}], "href": "https://doi.org/10.1074/jbc.M114.583450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25164816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25164816"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Min Pi, L Darryl Quarles "}, {"type": "b", "children": [{"type": "t", "text": "GPRC6A regulates prostate cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.21442"}], "href": "https://doi.org/10.1002/pros.21442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21681779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21681779"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ruisong Ye, Min Pi, John V Cox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-017-0561-x"}], "href": "https://doi.org/10.1186/s13046-017-0561-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28659174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28659174"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Andrea Di Nisio, Maria Santa Rocca, Gian Paolo Fadini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Endocrinol (Oxf) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cen.13248"}], "href": "https://doi.org/10.1111/cen.13248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27696500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27696500"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qihang Hou, Jingxi Huang, Xia Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Crohns Colitis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ecco-jcc/jjac020"}], "href": "https://doi.org/10.1093/ecco-jcc/jjac020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35134872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35134872"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Min Pi, Pieter Faber, George Ekema, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel extracellular cation-sensing G-protein-coupled receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505186200"}], "href": "https://doi.org/10.1074/jbc.M505186200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16199532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16199532"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Petrine Wellendorph, Kasper B Hansen, Anders Balsgaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.104.007559"}], "href": "https://doi.org/10.1124/mol.104.007559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15576628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15576628"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Min Pi, Satoru Kenneth Nishimoto, L Darryl Quarles "}, {"type": "b", "children": [{"type": "t", "text": "GPRC6A: Jack of all metabolism (or master of none)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2016.12.006"}], "href": "https://doi.org/10.1016/j.molmet.2016.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28180060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28180060"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Luca De Toni, Andrea Di Nisio, Elena Speltra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2015-3967"}], "href": "https://doi.org/10.1210/jc.2015-3967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26735260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26735260"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Konstantina Kalyvianaki, Athanasios A Panagiotopoulos, Panagiotis Malamos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Steroids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.steroids.2019.01.006"}], "href": "https://doi.org/10.1016/j.steroids.2019.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30707908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30707908"}]}]}]}
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| Synonyms | BA86F4.3 |
| Proteins | GPC6A_HUMAN |
| NCBI Gene ID | 222545 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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GPRC6A has 2,960 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 84 datasets.
Click the + buttons to view associations for GPRC6A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of GPRC6A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of GPRC6A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of GPRC6A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GPRC6A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GPRC6A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPRC6A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of GPRC6A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GPRC6A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of GPRC6A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of GPRC6A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of GPRC6A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing GPRC6A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with GPRC6A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with GPRC6A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPRC6A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with GPRC6A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with GPRC6A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by GPRC6A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for GPRC6A protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with GPRC6A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with GPRC6A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with GPRC6A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with GPRC6A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with GPRC6A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GPRC6A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GPRC6A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of GPRC6A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with GPRC6A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with GPRC6A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with GPRC6A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing GPRC6A from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of GPRC6A gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving GPRC6A gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving GPRC6A gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving GPRC6A gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing GPRC6A protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by GPRC6A gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by GPRC6A gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by GPRC6A gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of GPRC6A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of GPRC6A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding GPRC6A receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with GPRC6A gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with GPRC6A gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with GPRC6A gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with GPRC6A gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of GPRC6A gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for GPRC6A protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with GPRC6A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by GPRC6A gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for GPRC6A protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of GPRC6A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of GPRC6A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of GPRC6A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving GPRC6A protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPRC6A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of GPRC6A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain GPRC6A protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by GPRC6A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of GPRC6A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by GPRC6A gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| NURSA Protein Complexes | protein complexs containing GPRC6A protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GPRC6A gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving GPRC6A protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving GPRC6A protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving GPRC6A protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving GPRC6A protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GPRC6A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of GPRC6A gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of GPRC6A gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of GPRC6A gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of GPRC6A gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of GPRC6A gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of GPRC6A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of GPRC6A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of GPRC6A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with GPRC6A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with GPRC6A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving GPRC6A protein from the Wikipathways Pathways 2014 dataset. | |
