{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNAs (lncRNAs) are important regulators of gene expression, acting as decoy molecules, signals, scaffolds, and guides by interacting with DNA, chromatin‐modifying complexes, and transcriptional regulators. GRASLND (also known as RNF144A‑AS1) was first recognized for its role in modulating chondrogenic differentiation in mesenchymal stem cells, illustrating its capacity to affect key cellular processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Recent investigations have indicated that GRASLND exerts regulatory effects in cancers. In glioma—a malignant tumor of the central nervous system—its role remains to be fully elucidated even though initial findings underscore its potential involvement in tumor biology, thereby warranting further study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In addition, emerging evidence points to an oncogenic function of GRASLND in various malignancies, including skin cutaneous melanoma. Such findings highlight its promise as both a diagnostic marker and a therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Wu, Xiaolan Li, Xueqing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Role of Long Non-Coding RNF144A-AS1 in Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-024-01411-9"}], "href": "https://doi.org/10.1007/s12013-024-01411-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39014185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39014185"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaofei Tong, Zhi Yang, Qian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF144A-AS1 promotes the development of glioma cells by targeting miR-665/HMGA1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2021.136259"}], "href": "https://doi.org/10.1016/j.neulet.2021.136259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34560189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34560189"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aiwei Ma, Wenqi Shi, Liyun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRASLND regulates melanoma cell progression by targeting the miR-218-5p/STAM2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-024-05397-z"}], "href": "https://doi.org/10.1186/s12967-024-05397-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39060946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39060946"}]}]}]}