{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long non‐coding RNA LINC00514 is emerging as an oncogenic regulator in diverse human cancers. In papillary thyroid cancer, LINC00514 is markedly upregulated and its silencing reduces cell proliferation, migration, and invasion while promoting apoptosis; similarly, its aberrant expression in pancreatic cancer has been associated with a poor prognosis, suggesting its potential as a prognostic biomarker in this aggressive malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations in gastric and thyroid cancers have revealed that LINC00514 can function as a competing endogenous RNA. In papillary thyroid cancer, it sequesters miR‑204‑3p thereby relieving repression on CDC23, whereas in gastric cancer LINC00514 similarly sponges miR‑204‑3p to enhance KRAS expression. This miRNA‐mediated regulation contributes to increased cell growth and facilitates the epithelial–mesenchymal transition, underscoring its role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies in esophageal squamous cell carcinoma and non‑small cell lung cancer further demonstrate the multifaceted oncogenic functions of LINC00514. In esophageal cancer, LINC00514 promotes proliferation, invasion, and lipogenesis by sponging miR‑1378a‑15p, resulting in increased expression of SPHK1 and activation of lipogenesis‐related pathways. In non‑small cell lung cancer, elevated LINC00514 levels activate the Wnt/β‑catenin signaling pathway to induce epithelial–mesenchymal transition and enhance tumor aggressiveness. Collectively, these findings highlight LINC00514 as a crucial driver of tumor progression and a promising target for therapeutic intervention across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangya Li, Wen Zhong, Yiling Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.12.051"}], "href": "https://doi.org/10.1016/j.bbrc.2018.12.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30553447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30553447"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qing Han, Junhe Li, Jianping Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01660-5"}], "href": "https://doi.org/10.1186/s13046-020-01660-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32771045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32771045"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ling Yuan, Jiaxin Li, Yi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202905"}], "href": "https://doi.org/10.18632/aging.202905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33888645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33888645"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xin Wang, Hongtao Liu, Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2021.5266"}], "href": "https://doi.org/10.3892/ijo.2021.5266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34533201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34533201"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuanzhe Zhu, Huala Wu, Xi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2084246"}], "href": "https://doi.org/10.1080/21655979.2022.2084246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35653786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35653786"}]}]}]}