GRIK3 Gene

HGNC Family	Ion channels, Glutamate receptors
Name	glutamate receptor, ionotropic, kainate 3
Description	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The kainate receptor subunit encoded by the GRIK3 gene (also known as GluR7) has emerged as a multifunctional player in both the central nervous system and in peripheral tissues. In neurons, alternative splicing of GRIK3 generates receptor variants with distinct trafficking properties that determine cell‐surface expression and synaptic localization; for example, the GluR7a isoform is efficiently delivered to the plasma membrane, whereas GluR7b is largely retained intracellularly, thereby modulating excitatory neurotransmission and synaptic plasticity (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Genetic studies have revealed that specific functional polymorphisms in GRIK3—such as the T928G (Ser310Ala) variant—are associated with an increased susceptibility to mood disorders including recurrent major depression and schizophrenia, as well as with personality traits typified by heightened harm avoidance, suggesting that subtle alterations in receptor properties may influence higher cognitive and emotional processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": " Moreover, copy number aberrations that reduce GRIK3 expression have been implicated in severe developmental delay, highlighting the gene’s importance in proper neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Beyond the nervous system, aberrant overexpression of GRIK3 has been observed in malignancies such as breast and colorectal cancers, where its upregulation appears to promote cellular proliferation, migration, and epithelial‐mesenchymal transition via pathways involving key regulators like SPDEF, CDH1, and β‐catenin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, investigations into alcohol withdrawal phenomena have suggested a link between the Ser310 allele of GRIK3 and an increased risk for delirium tremens, although further work is needed to clarify its role in alcohol-related conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Together, these studies indicate that GRIK3 is critical for regulating excitatory synaptic transmission through isoform‐dependent trafficking and that its genetic and expression variations contribute to a broad spectrum of pathophysiological outcomes encompassing neuropsychiatric disorders, neurodevelopmental deficits, and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Frédéric Jaskolski, Elisabeth Normand, Christophe Mulle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential trafficking of GluR7 kainate receptor subunit splice variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413166200"}], "href": "https://doi.org/10.1074/jbc.M413166200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15805114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15805114"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Deborah Huyghe, Julien Veran, Virginie F Labrousse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2206-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.2206-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21832194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21832194"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "H H Schiffer, S F Heinemann "}, {"type": "b", "children": [{"type": "t", "text": "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30374"}], "href": "https://doi.org/10.1002/ajmg.b.30374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16958029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16958029"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Begni, M Popoli, S Moraschi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4000987"}], "href": "https://doi.org/10.1038/sj.mp.4000987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11986986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11986986"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alessandra Minelli, Catia Scassellati, Cristian Bonvicini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An association of GRIK3 Ser310Ala functional polymorphism with personality traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychobiology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000202827"}], "href": "https://doi.org/10.1159/000202827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19221446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19221446"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "S Djurovic, A K Kähler, B Kulle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.schres.2008.10.010"}], "href": "https://doi.org/10.1016/j.schres.2008.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19022628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19022628"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gamze Kilic, Cem Ismail Kucukali, Nurcan Orhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatry Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.psychres.2008.10.001"}], "href": "https://doi.org/10.1016/j.psychres.2008.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19995671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19995671"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Toshiki Takenouchi, Noriko Hashida, Chiharu Torii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36240"}], "href": "https://doi.org/10.1002/ajmg.a.36240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24449200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24449200"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bin Xiao, Zhenzhan Kuang, Weiyun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23014"}], "href": "https://doi.org/10.1002/mc.23014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30977227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30977227"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guojiu Fang, Yibin Wu, Xueli Zhang "}, {"type": "b", "children": [{"type": "t", "text": "CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-021-02275-6"}], "href": "https://doi.org/10.1186/s12957-021-02275-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34127015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34127015"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "U W Preuss, P Zill, G Koller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.tpj.6500343"}], "href": "https://doi.org/10.1038/sj.tpj.6500343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314883"}]}]}]}
Synonyms	GLUR7A, EAA5, GLUR7, GLR7, GLUK3
Proteins	GRIK3_HUMAN
NCBI Gene ID	2899
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GRIK3 has 4,766 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for GRIK3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GRIK3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by GRIK3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRIK3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRIK3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GRIK3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GRIK3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GRIK3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRIK3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GRIK3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRIK3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRIK3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GRIK3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRIK3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GRIK3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GRIK3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRIK3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GRIK3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GRIK3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GRIK3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GRIK3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GRIK3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GRIK3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GRIK3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRIK3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GRIK3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GRIK3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GRIK3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GRIK3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with GRIK3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with GRIK3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GRIK3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GRIK3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GRIK3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GRIK3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for GRIK3 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GRIK3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRIK3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GRIK3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GRIK3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with GRIK3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with GRIK3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.