GRK5 Gene

Name	G protein-coupled receptor kinase 5
Description	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n G protein–coupled receptor kinase 5 (GRK5) is emerging as a multifunctional serine/threonine kinase that not only desensitizes activated G protein–coupled receptors (GPCRs) through receptor phosphorylation and subsequent β‐arrestin recruitment but also regulates a spectrum of intracellular events. For example, GRK5‐dependent phosphorylation of β2‐adrenergic and follicle‐stimulating hormone receptors promotes the formation of stable receptor–β‐arrestin complexes that mediate sustained extracellular signal–regulated kinase (ERK) activation independent of classical G protein signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, GRK5 participates in β‐arrestin–biased responses that extend to the regulation of microRNA biogenesis in cardiomyocytes, thereby contributing to cardioprotective pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its canonical actions at the plasma membrane, GRK5 can translocate to the nucleus where it modulates transcription. Nuclear GRK5 interacts directly with key regulators such as IκBα, leading to altered nuclear factor–κB (NF‑κB) activity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and phosphorylates p53 to promote its degradation, thereby influencing cell survival and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Such nuclear signaling functions are important in the context of cardiac hypertrophy, as GRK5 phosphorylates class II histone deacetylases to regulate maladaptive gene transcription associated with heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n GRK5 also affects receptor signaling in other systems. Variants in GRK5 modulate β‑adrenergic receptor desensitization in airway smooth muscle, contributing to altered responses in asthma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while in innate immunity, GRK5 acts as a positive regulator of Toll‐like receptor 4–induced cytokine production by enhancing NF‑κB activation in macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the nervous system, GRK5 influences opioid receptor signaling—where its selective mediation of receptor phosphorylation by morphine impacts antinociception and physical dependence"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "—and phosphorylates α‑synuclein, modulating dopamine transporter function and aggregate clearance in Parkinson disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, GRK5 regulates cell migration and proliferation through non–GPCR‐mediated mechanisms. It affects prostate cancer cell adhesion and motility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and localizes to centrosomes to govern microtubule nucleation and normal cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Finally, by being selectively recruited by distinct ligands—such as purinergic agents during oligodendrocyte precursor cell differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "and by the endothelial protein C receptor during protease‑activated receptor 1 signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "—GRK5 contributes to the fine tuning of physiological responses in diverse tissues. Furthermore, GRK5 deficiency has been linked to early Alzheimer disease, highlighting its relevance in neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings reveal that GRK5 functions as a critical integrator of plasma membrane signaling and nuclear transcriptional regulation, orchestrating responses that range from receptor desensitization and biased agonism to modulation of gene expression and cell cycle progression. Its diverse roles underpin its involvement in cardiovascular homeostasis, inflammatory and immune responses, neurodegenerative processes, and even tumor cell migration, making GRK5 a promising target for novel therapeutic approaches.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sudha K Shenoy, Matthew T Drake, Christopher D Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506576200"}], "href": "https://doi.org/10.1074/jbc.M506576200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16280323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16280323"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elodie Kara, Pascale Crépieux, Christophe Gauthier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2006-0098"}], "href": "https://doi.org/10.1210/me.2006-0098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16887887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16887887"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Il-Man Kim, Yongchao Wang, Kyoung-Mi Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.114.302766"}], "href": "https://doi.org/10.1161/CIRCRESAHA.114.302766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24334028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24334028"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daniela Sorriento, Michele Ciccarelli, Gaetano Santulli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0804446105"}], "href": "https://doi.org/10.1073/pnas.0804446105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19008357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19008357"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoqing Chen, Huiling Zhu, Man Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.094243"}], "href": "https://doi.org/10.1074/jbc.M109.094243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20124405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20124405"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jessica I Gold, Erhe Gao, Xiying Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.112.273367"}], "href": "https://doi.org/10.1161/CIRCRESAHA.112.273367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22859683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22859683"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wayne C H Wang, Kathryn A Mihlbachler, Eugene R Bleecker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e32830967e9"}], "href": "https://doi.org/10.1097/FPC.0b013e32830967e9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18622265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18622265"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sonika Patial, Shipra Shahi, Yogesh Saini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22460"}], "href": "https://doi.org/10.1002/jcp.22460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20945396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20945396"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Laura Glück, Anastasia Loktev, Lionel Moulédous, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2014.01.021"}], "href": "https://doi.org/10.1016/j.biopsych.2014.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24629717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24629717"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hedieh Shahpasandzadeh, Blagovesta Popova, Alexandra Kleinknecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.559237"}], "href": "https://doi.org/10.1074/jbc.M114.559237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25231978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25231978"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Prabir Kumar Chakraborty, Yushan Zhang, Alexandra S Coomes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-2708"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-2708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24755472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24755472"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Allison M Michal, Christopher H So, Neil Beeharry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.298034"}], "href": "https://doi.org/10.1074/jbc.M111.298034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22223642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22223642"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Simona Daniele, Maria Letizia Trincavelli, Marta Fumagalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Does GRK-β arrestin machinery work as a \"switch on\" for GPR17-mediated activation of intracellular signaling pathways?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2014.02.016"}], "href": "https://doi.org/10.1016/j.cellsig.2014.02.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24613411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24613411"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ram Vinod Roy, Abdolreza Ardeshirylajimi, Peyman Dinarvand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-06-720581"}], "href": "https://doi.org/10.1182/blood-2016-06-720581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27561318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27561318"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhiming Suo, April A Cox, Nicholas Bartelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2006.08.013"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2006.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17011668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17011668"}]}]}]}
Synonyms	FP2025, GPRK5
Proteins	GRK5_HUMAN
NCBI Gene ID	2869
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GRK5 has 8,437 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 132 datasets.

Click the + buttons to view associations for GRK5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GRK5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by GRK5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GRK5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GRK5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GRK5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GRK5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRK5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRK5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GRK5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRK5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GRK5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with GRK5 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GRK5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRK5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GRK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GRK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of GRK5 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GRK5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GRK5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GRK5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing GRK5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GRK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GRK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRK5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GRK5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GRK5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GRK5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of GRK5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GRK5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for GRK5 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with GRK5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with GRK5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GRK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GRK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GRK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GRK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GRK5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRK5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.