{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies have provided insights into the regulation of long noncoding RNAs (lncRNAs) in different disease contexts. In a study profiling lncRNAs in epithelial ovarian cancer, a broad dysregulation of lncRNAs was observed, with many transcripts implicated in cell cycle regulation and cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this study did not specifically focus on GRTP1‐AS1, it set the stage for recognizing the importance of antisense lncRNAs in disease processes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation addressing the mechanisms of integrated traditional Chinese medicine in alleviating sciatica, GRTP1‐AS1 was identified as one of several genes whose expression was significantly decreased in the peripheral blood following treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This reduction, in parallel with pain relief, suggests that GRTP1‐AS1 may be involved in mediating inflammatory and immune responses related to sciatica. Its modulation could reflect a broader regulatory role in the inflammatory pathways that contribute to the symptomatic state.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings imply that while lncRNAs—including antisense variants—play diverse roles in pathological conditions, GRTP1‐AS1 in particular emerges as a potential biomarker or functional contributor to the inflammatory processes underlying sciatica. Further studies will be critical to elucidate whether GRTP1‐AS1 directly participates in the modulation of immune pathways and how it might serve as a target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huan Wang, Ziyi Fu, Chencheng Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep38983"}], "href": "https://doi.org/10.1038/srep38983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27941916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27941916"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yi Wang, Guogang Dai, Yan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated traditional Chinese medicine alleviates sciatica while regulating gene expression in peripheral blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-021-02280-1"}], "href": "https://doi.org/10.1186/s13018-021-02280-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33573686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33573686"}]}]}]}