{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe set of provided abstracts addresses diverse mechanisms underlying cell–cell junction formation, inflammation‐related signaling pathways, and transcriptional regulation in a number of physiological and pathological contexts, including renal magnesium and calcium transport, oncogenic proliferation, and fibrogenesis. For example, several studies detail how claudin‐16 and claudin‐19 interact to assemble tight junction structures that govern cation-selective paracellular transport in the kidney."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther contributions focus on the activation of oncogenic and inflammatory signaling pathways—illustrated by the constitutive signaling of the viral receptor US28 that triggers the IL-6–JAK1–STAT3 cascade"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "—and on the regulatory actions of transcription factor complexes such as STRA13 and the Elongator complex subunit ELP2 (also known as STAT3-interacting protein 1). These proteins are implicated in processes ranging from apoptosis, osteoblast differentiation, and even neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further study highlights novel roles for a circular RNA derived from ELP2 (circELP2) in promoting pulmonary fibrogenesis via microRNA sponging and downstream regulation of mitochondrial quality control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " It is important to note, however, that none of these abstracts provide any information regarding GSTT4. Despite the rich discussion of proteins governing tight junction integrity, inflammatory cascades, and transcriptional modulation, the function of GSTT4 is not addressed in this collection of studies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A V Ivanova, S V Ivanov, X Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.05.025"}], "href": "https://doi.org/10.1016/j.jmb.2004.05.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15223310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15223310"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianghui Hou, Aparna Renigunta, Antonio S Gomes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0907724106"}], "href": "https://doi.org/10.1073/pnas.0907724106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706394"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Henrik Dimke, Camille Griveau, Wung-Man Evelyne Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Claudin-19 localizes to the thick ascending limb where its expression is required for junctional claudin-16 localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/nyas.15014"}], "href": "https://doi.org/10.1111/nyas.15014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37344378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37344378"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroaki Okuda, Takayuki Manabe, Takeshi Yanagita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2006.06.009"}], "href": "https://doi.org/10.1016/j.mcn.2006.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16870469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16870469"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Erik Slinger, David Maussang, Andreas Schreiber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2001180"}], "href": "https://doi.org/10.1126/scisignal.2001180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20682912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20682912"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "John M Luk, Man-Kit Tong, Bobo W Mok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.11.010"}], "href": "https://doi.org/10.1016/j.febslet.2004.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15589828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15589828"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chang-Peng Xu, Xue Li, Yan-Jun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2014.11.002"}], "href": "https://doi.org/10.1016/j.jprot.2014.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25486498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25486498"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yasunori Saitoh, Hiroshi Suzuki, Kazutoshi Tani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1261833"}], "href": "https://doi.org/10.1126/science.1261833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25678664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25678664"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shan Lu, Hong-Wu Fan, Kai Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Elp2 prevents renal fibrosis and inflammation induced by unilateral ureter obstruction (UUO) via inactivating Stat3-regulated TGF-β1 and NF-κB pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.227"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29723529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29723529"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Marija Kojic, Tomasz Gawda, Monika Gaik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-22888-5"}], "href": "https://doi.org/10.1038/s41467-021-22888-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33976153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33976153"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Songzi Zhang, Diwei Tu, Weili Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circELP2 reverse-splicing biogenesis and function as a pro-fibrogenic factor by targeting mitochondrial quality control pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.18098"}], "href": "https://doi.org/10.1111/jcmm.18098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38159063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38159063"}]}]}]}