{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSENP7 is a SUMO-specific protease that plays a pivotal role in heterochromatin stability by deSUMOylating HP1α, thereby ensuring its proper retention at pericentric heterochromatin. Loss of SENP7 disrupts this process, causing HP1α mislocalization without altering H3K9me3 levels, and thus underscoring its importance in chromatin architecture and genome stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "SENP7 is also essential in the realm of mammalian reproduction where it regulates key epigenetic events. In mouse oocytes, SENP7 deficiency leads to meiotic arrest and spindle assembly defects due to imbalances in histone modifications and misregulation of cell cycle regulators, ultimately compromising the maternal‐zygotic transition and embryo viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Furthermore, during neuronal differentiation, transient upregulation of SENP7 is crucial for initiating neurogenesis. Its activity fosters the differentiation process both in cultured neuronal models and in the developing neural tube, indicating that precise modulation of SUMO conjugation is fundamental for early neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "In the context of lipid homeostasis, SENP7 contributes to the maturation of lipid droplets in adipocytes. It achieves this by deSUMOylating the perilipin family protein Plin4, which is necessary for appropriate lipid droplet growth and overall maintenance of white adipose tissue mass."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christèle Maison, Kelly Romeo, Delphine Bailly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2244"}], "href": "https://doi.org/10.1038/nsmb.2244"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22388734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22388734"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chun-Jie Huang, Di Wu, Xiao-Fei Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal SENP7 programs meiosis architecture and embryo survival in mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2017.03.005"}], "href": "https://doi.org/10.1016/j.bbamcr.2017.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28315713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28315713"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Francisco Juarez-Vicente, Noelia Luna-Pelaez, Mario Garcia-Dominguez "}, {"type": "b", "children": [{"type": "t", "text": "The Sumo protease Senp7 is required for proper neuronal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2016.03.028"}], "href": "https://doi.org/10.1016/j.bbamcr.2016.03.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27039038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27039038"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jingwen Pei, Dayuan Zou, Lu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2024.107319"}], "href": "https://doi.org/10.1016/j.jbc.2024.107319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38677512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38677512"}]}]}]}