{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2AC1, a member of the histone H2A family, functions as a signal‐responsive regulator of chromatin structure and gene expression. Although several histone variants (for example, H2A.Z ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]) are known to modulate nucleosome stability, H2AC1 is characterized by a unique pattern of post‐translational modifications. In particular, phosphorylation and methylation events on H2AC1 serve as a regulatory “switch” that affects its incorporation into nucleosomes and its interaction with chromatin‐organizing factors such as heterochromatin protein 1α (HP1α). Enhanced methylation on H2AC1—accompanied by a decrease in phosphorylation—appears to promote binding to HP1α, thus facilitating the formation or maintenance of condensed chromatin domains. Importantly, these modifications are not static; they change in response to extracellular cues such as G protein–coupled receptor activation (e.g., via angiotensin II type 1 receptor signaling), thereby linking receptor‐mediated signals to dynamic chromatin remodeling and transcriptional regulation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "].\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Toyotaka Ishibashi, Deanna Dryhurst, Kristie L Rose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi900196c"}], "href": "https://doi.org/10.1021/bi900196c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19385636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19385636"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rajaganapathi Jagannathan, Suma Kaveti, Russell W Desnoyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012552"}], "href": "https://doi.org/10.1371/journal.pone.0012552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20838438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20838438"}]}]}]}