H2AP Gene

Name H2A.P histone
Description This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in individuals with Huntington's disease (PMID: 9700202). [provided by RefSeq, Aug 2011]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2AP is understood to be a variant member of the H2A histone family—a group of proteins that are essential for packaging genomic DNA into nucleosomes and thereby establishing the chromatin framework that regulates gene expression, DNA repair, and recombination. In its role as a core chromatin component, H2AP’s conserved histone fold domain facilitates the assembly and dynamic remodeling of nucleosomes, which in turn modulates the accessibility of DNA to transcription factors and other regulatory complexes. Progress in bioinformatic resources—particularly comprehensive sequence alignments and structural databases of histone and histone fold–containing proteins—has enhanced our understanding of H2AP’s structure–function relationships and its evolutionary conservation across diverse species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leonardo Mariño-Ramírez, Kevin M Levine, Mario Morales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Histone Database: an integrated resource for histones and histone fold-containing proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Database (Oxford) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/database/bar048"}], "href": "https://doi.org/10.1093/database/bar048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22025671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22025671"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Leonardo Mariño-Ramírez, Benjamin Hsu, Andreas D Baxevanis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Histone Database: a comprehensive resource for histones and histone fold-containing proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteins (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/prot.20814"}], "href": "https://doi.org/10.1002/prot.20814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16345076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16345076"}]}]}]}
NCBI Gene ID 25763
API
Download Associations
Predicted Functions View H2AP's ARCHS4 Predicted Functions.
Co-expressed Genes View H2AP's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View H2AP's ARCHS4 Predicted Functions.

Functional Associations

H2AP has 946 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for H2AP from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of H2AP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of H2AP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of H2AP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with H2AP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with H2AP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving H2AP gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2025 cellular components containing H2AP protein from the curated GO Cellular Component Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of H2AP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by H2AP gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of H2AP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of H2AP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of H2AP gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of H2AP gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of H2AP gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of H2AP gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of H2AP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of H2AP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with H2AP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.