{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2BC15, a member of the histone H2B family, plays a fundamental role in chromatin organization and transcriptional regulation. Its incorporation into nucleosomes helps establish the higher‐order chromatin structure, thereby influencing gene expression and cellular homeostasis. In prostate cancer, upregulation of H2BC15 has been shown to promote tumor cell proliferation, migration, and epithelial–mesenchymal transition by enhancing NF‑κB signaling, which suggests that it functions as part of an oncogenic regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in ovarian cancer, hypomethylation of H2BC15 is an independent predictor of poor progression‐free and overall survival, indicating that epigenetic deregulation of this histone gene contributes to aggressive disease phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, cross‑disorder genome‐wide analyses have identified H2BC15 among a panel of histone genes commonly associated with multiple psychiatric conditions—including schizophrenia, bipolar disorder, and depression—implying a possible role in neural chromatin remodeling and transcriptional control relevant to neuropsychiatric pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these studies underscore the multifaceted involvement of H2BC15 in modulating chromatin dynamics, with significant implications for oncogenesis and neuropsychiatric disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juan Zhang, Yuhan Chang, Haiyan Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-021-01164-2"}], "href": "https://doi.org/10.1007/s13258-021-01164-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34537918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34537918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Ping Liao, Lin-Yu Chen, Rui-Lan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddt583"}], "href": "https://doi.org/10.1093/hmg/ddt583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24256813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24256813"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yulu Wu, Hongbao Cao, Ancha Baranova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-trait analysis for genome-wide association study of five psychiatric disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-020-00902-6"}], "href": "https://doi.org/10.1038/s41398-020-00902-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32606422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32606422"}]}]}]}