| Name | H2B clustered histone 21 |
| Description | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2BC21 encodes a replication‐dependent histone H2B that is an integral structural component of nucleosomes and plays a central role in chromatin organization and gene regulation. Its expression is tightly controlled during the cell cycle – for example, specific transcriptional activator complexes (such as OCA‑S, which involves a nuclear form of GAPDH) selectively drive H2B transcription during S phase in response to metabolic cues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, H2B undergoes critical posttranslational modifications that influence chromatin dynamics and transcriptional output. Notably, monoubiquitination of H2B at lysine 120—mediated by E2 and E3 enzymes including RAD6/UbcH6 together with RNF20/40—facilitates transcription elongation by stimulating subsequent methylation of histone H3 at key lysine residues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " These modifications serve as a regulatory “bridge” between nucleosome remodeling and RNA polymerase II–mediated transcription, ensuring coordinated gene expression and maintenance of genomic integrity. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Zheng, Robert G Roeder, Yan Luo "}, {"type": "b", "children": [{"type": "t", "text": "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00552-x"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00552-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12887926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12887926"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jaehoon Kim, Mohamed Guermah, Robert K McGinty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.02.027"}], "href": "https://doi.org/10.1016/j.cell.2009.02.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19410543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19410543"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bing Zhu, Yong Zheng, Anh-Dung Pham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.09.025"}], "href": "https://doi.org/10.1016/j.molcel.2005.09.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16307923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16307923"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rushad Pavri, Bing Zhu, Guohong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.04.029"}], "href": "https://doi.org/10.1016/j.cell.2006.04.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16713563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16713563"}]}]}]}
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| NCBI Gene ID | 8349 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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H2BC21 has 6,347 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.
Click the + buttons to view associations for H2BC21 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of H2BC21 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of H2BC21 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of H2BC21 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing H2BC21 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with H2BC21 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with H2BC21 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with H2BC21 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving H2BC21 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing H2BC21 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of H2BC21 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with H2BC21 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of H2BC21 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving H2BC21 protein from the KEGG Pathways 2026 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of H2BC21 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of H2BC21 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| Reactome Pathways 2024 | pathways involving H2BC21 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of H2BC21 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of H2BC21 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of H2BC21 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of H2BC21 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of H2BC21 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of H2BC21 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of H2BC21 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with H2BC21 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving H2BC21 protein from the WikiPathways Pathways 2024 dataset. | |
