{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2BC6 is one of the replication‐dependent histone H2B variants that, while primarily serving its classical role as a core component of nucleosomal chromatin to help regulate DNA packaging and gene expression, also appears to be involved in non‐canonical functions during disease. For example, in studies of chronic rhinosinusitis with nasal polyps the transcript for HIST1H2BC was found to be upregulated among a panel of dysregulated antimicrobial peptides; this finding suggests that H2BC6 may be released or otherwise co‐opted into extracellular roles that contribute to local innate immune defense and inflammatory modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in triple‐negative breast cancer, mutations affecting HIST1H2BC have been identified among a set of genes whose altered mutational frequencies correlate with differences in tumor immune cell infiltration. This observation implies that alterations in H2BC6 may influence the tumor microenvironment, possibly impacting mechanisms of immune recognition or evasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings highlight the multifunctional nature of H2BC6: beyond its foundational role in chromatin structure and transcriptional regulation, H2BC6 may also participate in the modulation of immune responses in both inflammatory disorders and cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanran Huang, Ming Wang, Yu Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1057186"}], "href": "https://doi.org/10.1155/2021/1057186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33506054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33506054"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kelly E Craven, Yesim Gökmen-Polar, Sunil S Badve "}, {"type": "b", "children": [{"type": "t", "text": "CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-83913-7"}], "href": "https://doi.org/10.1038/s41598-021-83913-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33633150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33633150"}]}]}]}