{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n H2BC8 is a replication‐dependent histone H2B variant that plays a central role in the organization of chromatin and the regulation of gene expression. As a core component of the nucleosome, H2BC8 contributes to DNA packaging, cell cycle progression, and maintenance of genomic stability. Its transcription is subject to regulation by key proliferative factors such as FOXM1, which directly transactivates histone H2B promoters to ensure proper expression during S‐phase and mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, the post‐translational modification of H2B—including reversible ubiquitylation mediated by deubiquitylating enzymes like USP42—further fine-tunes transcriptional output and influences epigenetic landscapes critical for cell differentiation and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, altered expression of H2BC8 has been observed in disease settings; for instance, upregulation of HIST1H2BC, which encodes H2BC8, has been documented among differentially expressed antimicrobial peptides in nasal tissues from patients with chronic rhinosinusitis with nasal polyps, suggesting a possible link between chromatin dynamics and local immune defense or tissue remodeling processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted roles of H2BC8 in both normal cellular functions and disease-related alterations in chromatin structure and transcriptional regulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Inken Wierstra, Jürgen Alves "}, {"type": "b", "children": [{"type": "t", "text": "FOXM1, a typical proliferation-associated transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/BC.2007.159"}], "href": "https://doi.org/10.1515/BC.2007.159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18020943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18020943"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andreas K Hock, Arnaud M Vigneron, Karen H Vousden "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.589267"}], "href": "https://doi.org/10.1074/jbc.M114.589267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25336640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25336640"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanran Huang, Ming Wang, Yu Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1057186"}], "href": "https://doi.org/10.1155/2021/1057186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33506054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33506054"}]}]}]}