{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Histone H2B family members are core components of nucleosomes that package DNA into chromatin and thereby influence fundamental processes such as transcription regulation, DNA repair, and replication. Quantitative mass‐spectrometry studies have revealed that H2B isoforms, including H2BW2, are expressed at varying levels across different cell types and cancer lines. Although these isoforms share similar post‐translational modification profiles—for example, comparable acetylation levels—their relative abundance differs in a cell‐type–specific manner. In this context, H2BW2 is thought to contribute to the fine tuning of chromatin structure and epigenetic status, potentially affecting tissue‐specific gene regulation and cellular identity. Furthermore, while the synthesis of canonical histones is tightly coupled to the cell cycle, certain H2B isoforms (including H2BW2) appear to be regulated independently of S‐phase histone expression, suggesting that they might play specialized roles outside of DNA replication. Together, these observations underscore a putative role for H2BW2 in modulating local chromatin dynamics, with possible implications in oncogenic transformation and other disease processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rosalynn C Molden, Natarajan V Bhanu, Gary LeRoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics Chromatin (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13072-015-0006-8"}], "href": "https://doi.org/10.1186/s13072-015-0006-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25922622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25922622"}]}]}]}