{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe transcription factor DUX4 transiently induces the expression of specific histone variants—H3.X and H3.Y (hereafter H3Y2 refers to the H3.Y variant)—in myoblasts. H3Y2 is rapidly incorporated throughout the gene bodies of DUX4-induced target genes after a brief DUX4 pulse. Its presence in chromatin appears to maintain an open and active configuration, thereby prolonging gene activity and enhancing the ability to rapidly re‐activate these genes upon subsequent DUX4 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn essence, H3Y2 functions as an epigenetic modifier that creates a “memory” of transient transcription factor activity. By stabilizing the active state of DUX4 target genes, H3Y2 facilitates sustained gene expression even after the initial activating signal has faded, suggesting a mechanism by which brief developmental or pathological cues can lead to prolonged transcriptional responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rebecca Resnick, Chao-Jen Wong, Danielle C Hamm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.10.025"}], "href": "https://doi.org/10.1016/j.celrep.2019.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31722199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31722199"}]}]}]}