HAPSTR1 Gene

Name HUWE1 associated protein modifying stress responses
Description Enables ubiquitin protein ligase binding activity. Involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHAPSTR1 (also known as C16ORF72/TAPR1) was first revealed as a gene whose deletion sensitizes p53‐positive cells to telomerase inhibition, pointing to a role in buffering the cellular consequences of telomere erosion. In cells with reduced telomerase activity, loss of TAPR1 leads to elevated p53 levels and enhanced activation of p53‐dependent transcriptional programs, thereby compromising cell fitness under stress. This function illustrates the gene's importance in modulating p53 responses and protecting cells from premature senescence when telomere integrity is at risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSubsequent genome‐scale fitness and transcriptomic analyses expanded the view of HAPSTR1 as a central rheostat in cellular stress adaptation. Diverse stressors—including DNA damage, nutrient deprivation, and proteotoxic insults—induce HAPSTR1 expression, which in turn orchestrates both cell‐autonomous and paracrine stress signaling pathways. Mechanistically, two equally abundant isoforms of HAPSTR1—sharing a conserved oligomerization domain—bind to the ubiquitin ligase HUWE1, a critical cofactor that not only facilitates HAPSTR1’s regulatory roles in stress signaling but also mediates feedback through its ubiquitination and destabilization. This pleiotropic function of HAPSTR1 supports the resilience of cells under a wide array of challenging conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yahya Benslimane, María Sánchez-Osuna, Jasmin Coulombe-Huntington, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.13331"}], "href": "https://doi.org/10.1111/acel.13331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33660365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33660365"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David R Amici, Daniel J Ansel, Kyle A Metz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2111262119"}], "href": "https://doi.org/10.1073/pnas.2111262119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35776542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35776542"}]}]}]}
NCBI Gene ID 29035
API
Download Associations
Predicted Functions View HAPSTR1's ARCHS4 Predicted Functions.
Co-expressed Genes View HAPSTR1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HAPSTR1's ARCHS4 Predicted Functions.

Functional Associations

HAPSTR1 has 1,319 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 20 datasets.

Click the + buttons to view associations for HAPSTR1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HAPSTR1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of HAPSTR1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of HAPSTR1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
GO Biological Process Annotations 2025 biological processes involving HAPSTR1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2025 cellular components containing HAPSTR1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by HAPSTR1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of HAPSTR1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of HAPSTR1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of HAPSTR1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with HAPSTR1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of HAPSTR1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of HAPSTR1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HAPSTR1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HAPSTR1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of HAPSTR1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of HAPSTR1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of HAPSTR1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of HAPSTR1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of HAPSTR1 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of HAPSTR1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.