{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HCG14 is a long non‐coding RNA that has been implicated in the regulation of gene expression in diverse pathologies. In celiac disease, HCG14 was identified within the major histocompatibility complex as an independent risk locus; its expression is modestly decreased in duodenal epithelial cells of affected patients, and polymorphisms in the HCG14 region correlate with lower expression levels of the innate immune receptor NOD1. These findings suggest that HCG14 may modulate immune signaling in the gut, thereby contributing to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In ovarian cancer, HCG14 has been recognized as one of several autophagy-related lncRNAs whose differential expression serves as an independent prognostic factor. Although its mechanistic role in tumor biology remains to be fully clarified, its association with autophagy-related pathways underscores the potential importance of HCG14 in mediating cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Izortze Santin, Amaia Jauregi-Miguel, Teresa Velayos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Celiac Diasease-associated lncRNA Named HCG14 Regulates NOD1 Expression in Intestinal Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Gastroenterol Nutr (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPG.0000000000001970"}], "href": "https://doi.org/10.1097/MPG.0000000000001970"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29601440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29601440"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chan Meng, Jie-Qiong Zhou, Yong-Sheng Liao "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy-related long non-coding RNA signature for ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060520970761"}], "href": "https://doi.org/10.1177/0300060520970761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33179541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33179541"}]}]}]}